Cyp2d6 - Study guides, Class notes & Summaries

ADME correct answer: Absorption Distribution Metabolism Elimination When a drug is absorbed, it can be one of 2 things correct answer: 1. Free drug (unbound, active and can readily cross cell membranes) 2. Protein-bound (usually inactive) Binding of drugs to receptors correct answer: Non-specific binding <——> specific binding —> desired biological effect **Distribution** Pharmacokinetics correct answer: Metabolism and elimination -what the body does to the dru...

Sertraline (Zoloft) Major Side Effects Answer insomnia, somnolence, HA, dry mouth, sex dysfunction, nausea & diarrhea Fluoxetine (Prozac) Major Side Effect Answer Activating (UPPER); AGITATION, INSOMNIA, nausea, vomiting, sex dysfunction, GI, serotonin syndrome Paraoxetine (Paxil) Major Side Effects Answer Anticholinergic (can't see, can't sleep, can't shit, can't spit), CYP2D6 inhibitor, increases TCA, phenothiazines, Type 1C antiarrhythmics, weight gain, GI, sex dysfuncti...

GMS 6510 PS7 Questions and Answers 100% Solved roughly what fraction of lung cancer cases could be prevented with the absence of smoking? -1/4 -1/6 -1/2 -6/8 -7/8 7/8 what functional group is formed on BaP that ultimately causes adduct formation? - ketone -alcohol -ester -nitrosamine -epoxide epoxide what enzyme is responsible for activating PAHs? -CYP2E1 -CYP1A1 -CYP1A2 -GSTM1 -CYP2D6 CYP1A1 in tobacco-associated COPD, is the ability of the body to respond to reactive oxygen...

Advanced Pharmacology Mock Rehearsal Exam| 2025/2026 Certification| Verified Q&A 1. What term describes the fraction of an administered drug that reaches the systemic circulation? Bioavailability 2. Which pharmacokinetic phase involves the movement of drugs from the bloodstream to the tissues? Distribution 3. In pharmacodynamics, what term describes the maximum effect a drug can produce, regardless of dose? Efficacy 4. Which process describes the body's ability to change dru...

G-Protien coupled receptors and how they interact with drugs - G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can stimulate t...

Cocaine sympathomimetics (stimulant) intranasal (50 min) Metabolized by: butyrylcholinesterase Metabolite: benzoylecgonine Inhibits (blocking) the reuptake: Dopamine, norepinephrine, serotonin Sympathomimetics (stimulant) Replacement or substitution therapy Bruxism, gum disease, cardiovascular effects Cocaine is primary taken? intranasal Cocaine's half-life 50 min Cocaine is metabolized by butyrlcholinesterase Metabolite: benzoylecgonine Cocaine's mechanism of action inhibits (block...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer d. The x-linked O...

Pharmacology Ch. 31 Opioid Analgesics & Antagonistswhat are the major therapeutic uses of opioid drugs? - correct answer analgesics antitussives antidiarrheal what are partial opioid agonists? what is the prototype of a strong analgesic or full agonist? - correct answer -partials exert less analgesia than morphine -morphine is the prototype which drugs undergo extensive 1st pass metabolism? - correct answer morphine hydromorphone oxymorphone what is an opiate? - correct answer drug deriv...

WGU D027 Practice Test Questions and answers, rated A+. verified. A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of ce...

MN553 Final Exam Answers 2023. MN553 Advanced Pharmacology & Pharmacotherapeutics It appears to be related to the decrease in aldosterone production. Presence of a dry, hacky cough indicates a high risk for this adverse response. Because it takes time to build up a blood level, it occurs after being on the drug for about 1 week. Question 2 4 / 4 points Jamison has been prescribed citalopram (Celexa) to treat his depression. Education regarding how quickly selective serotonin reuptake inhi...