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BBH 451 Midterm Exam Questions and Correct Answers
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Cocaine sympathomimetics (stimulant) intranasal (50 min) Metabolized by: butyrylcholinesterase Metabolite: benzoylecgonine Inhibits (blocking) the reuptake: Dopamine, norepinephrine, serotonin Sympathomimetics (stimulant) Replacement or substitution therapy Bruxism, gum disease, cardiovascula...

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  • August 26, 2024
  • 13
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • bbh 451 midterm exam questions and correct answers
  • cocaine sympathomimetics stimulant intranasal
  • metabolized by butyrylcholinesterase metabolite

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  • BBH 451
  • BBH 451

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BBH 451 Midterm Exam Questions and
Correct Answers
Cocaine sympathomimetics (stimulant) ✅intranasal

(50 min)

Metabolized by: butyrylcholinesterase
Metabolite: benzoylecgonine

Inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin

Sympathomimetics (stimulant)

Replacement or substitution therapy

Bruxism, gum disease, cardiovascular effects

Cocaine is primary taken? ✅intranasal

Cocaine's half-life ✅50 min

Cocaine is metabolized by ✅butyrlcholinesterase

Metabolite: benzoylecgonine

Cocaine's mechanism of action ✅inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin

Cocaine's side effects ✅bruxism, gum disease, cardiovascular effects

Cocaine's addiction therapy ✅replacement or substitution therapy

Amphetamine sympathomimetics (stimulant) ✅isomer/ d-amphetamine l-amphetamine

Oral and intranasal (recreationally)

(10 hours)

Metabolized by: p450 enzyme (CYP2D6)
Metabolite: alpha-hydroxy-amphetamine

, Mechanism of action:

Inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin

Inhibits VMAT-2 (neurotransmitters into vesicles)

Increased release of dopamine, norepinephrine, serotonin

ADHD treatment:
Adderall, lisdexamfetamine, methylphenidate (ritalin)

Stimulant psychosis, overdose, cardiovascular disease

Amphetamine is taken primarily? ✅oral and intranasal (recreational)

Amphetamines half-life? ✅10 hours

Amphetamines are metabolized by? ✅p450 enzyme - CYP2D6

Metabolite: alpha-hydroxy-amphetamine

Amphetamine mechanism of action ✅inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin

Inhibits VMAT-2 (neurotransmitters into vesicles)

Increased release of dopamine, norepinephrine, serotonin

Amphetamine ADHD treatment ✅adderall, lisdexfetamine, methylphenidate

Amphetamine side effects ✅stimulant psychosis, overdose, cardiovascular disease

Amphetamine isomer ✅d-amphetamine

L-amphetamine - racemic mixture

Methamphetamine ✅isomer/ d-methamphetamine l-methamphetamine

Intranasal, inhalation, injection

(up to 30 hours)

Metabolized by: p450 enzyme (CYP2D6)

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