Cyp2d6 - Study guides, Class notes & Summaries

Sertraline (Zoloft) Major Side Effects Answer insomnia, somnolence, HA, dry mouth, sex dysfunction, nausea & diarrhea Fluoxetine (Prozac) Major Side Effect Answer Activating (UPPER); AGITATION, INSOMNIA, nausea, vomiting, sex dysfunction, GI, serotonin syndrome Paraoxetine (Paxil) Major Side Effects Answer Anticholinergic (can't see, can't sleep, can't shit, can't spit), CYP2D6 inhibitor, increases TCA, phenothiazines, Type 1C antiarrhythmics, weight gain, GI, sex dysfuncti...

CYP2D6 - CORRECT ANSWER Need to increase doses of SSRI, beta blockers etc. Codeine can be deadly CYP2C9 - CORRECT ANSWER Decrease warfarin dose Test for gene VCORC1 mutation CYP3A4 - CORRECT ANSWER Decreases elimination Increase toxicity of Amio Schedule I - CORRECT ANSWER no accepted medical use in the US it may not be prescribed. heroin,various opium derivatives,hallucinogenic substances Schedule II - CORRECT ANSWER No refills, no telephone order...

Warfarin (Coumadin) - ️️CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via oxidation in the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein vitamin epoxide reductase complex, subunit 1 (VKORC1) Chronic Myelogenous Leukemia (CML) - ️️t(9;22) aka Philadelphia Chromosome, translocation occurs within two genes: the breakpoint cluster region (BCR) on chr.22 and the cellular counter part of the Abelson Leukemia virus tyrosine kinase (c-abl) o...

Chamberlain NR 565 - Advanced Pharmacology Midterm (Complete Solutions) | Latest Q&A 1. A patient with a confirmed MRSA infection has been prescribed vancomycin. What is an important nursing consideration when administering this medication? Monitor trough levels to prevent toxicity. 2. A nurse is administering gentamicin to a patient. Which assessment is crucial to monitor for toxicity? Hearing and renal function, as gentamicin can cause ototoxicity and nephrotoxicity. 3. Which ...

Risks of vaccines [minor SE: local tender, red, swelling at the injection site, low grade fever, behavioral changes within hours-day of administration] Vaccines are: Safe, effective, serious disease can occur in unvaccinated individuals for routine immunizations are among the safest and most reliable drugs available (most studied in kids) Factors that contribute to hesitancy Lack of information on vaccines Lack of information on diseases that vaccines prevent and their severity Informat...

Which CYP-interacting drugs increase the levels of propranolol and metoprolol? correct answers CYP2D6 inhibitors (e.g. amiodarone, paroxetine) How does digoxin benefit CHF? Atrial fibrillation? correct answers Digoxin is a mild positive ionotrope to help HF and is a negative chronotrope to help Afib. Which beta-blocker is more likely to cause CNS side effects, such as depression and insomnia? Why correct answers Propranolol will have more CNS side effects due to its greater lipid solubilit...

6521 Advanced Pharmacology Week 1| Complete Solutions| Module 1-5(Case Study Set) **Case Study 1** A parent asks the nurse why ibuprofen is not recommended for infants under six months of age. Which response by the nurse is correct? "Infants have immature renal function, which makes it harder for them to eliminate ibuprofen effectively." --- **Case Study 2** A nurse is caring for a 60-year-old patient with chronic kidney disease who has been prescribed Metformin for type...

Focus on Nursing Pharmacology - Amy M. Karch - Chapter 21 Exam with Complete Solutions 100% Solved What is main metabolism way of antidepressant? - answerHepatic metabolism Substrate of CY2D6? - answerTCA, venlafaxine Inhibitor of CYP2D6? - answerParoxetine Sertraline Fluoxetine Citalopram Duloxetine Inhibitor of CYP3A4 - answerFluoxetine Nefazodone Inhibitor of CYP1A2 - answerFluvoxamine What is CYP2D6 polymorphism? - answerDifferent patient will have from normal to different gene...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer. d. The x linked...

G-Protien coupled receptors and how they interact with drugs Correct Answer G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can st...