Use of isostere - Study guides, Class notes & Summaries
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BPS 2110 Midterm 2 Exam Questions And Correct Answers
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BPS 2110 Midterm 2 Exam Questions And Correct Answers...
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BPS2110 Midterm 2 Exam Questions and Answers 100% Solved
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BPS2110 Midterm 2 Exam Questions and 
Answers 100% Solved 
use of isostere - functional group replacements 
isostere - groups of atoms with similar sterics and electronics. 
give similar biological activity 
classical isostere - atoms or groups that have the same valency and 
similar size 
help determine if groups are important for binding 
EXAMPLE: OH = F, Cl, SH, NH2, CH3 
Non-classical isosteres - atoms or groups that have similar chemical 
properties (look for similar pka values) 
differ in ...
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