BPS2110 Midterm 2 Exam Questions and Answers 100% Solved
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Course
BPS
Institution
BPS
BPS2110 Midterm 2 Exam Questions and
Answers 100% Solved
use of isostere - functional group replacements
isostere - groups of atoms with similar sterics and electronics.
give similar biological activity
classical isostere - atoms or groups that have the same valency and
similar size
help det...
poor product because it was very insoluble in water which meant it required
a large dose. if you injected it too fast, the drug precipitated from veins and
stopped circulation. If injected too deep, it caused necrosis
Prontosil - ✔✔Dye that contains sulfa molecule; its use began the practice
of treating diseases with drugs
only effective in vivo
Sulfa drug mechanism of action - ✔✔interferes with bacterial growth
inhibits coenzyme F synthesis which stops bacterial growth (SN2 Rxn)
we don't naturally have CoF in our body so the drug is selective to only
bacteria
Sulfonamides - ✔✔competitive inhibitors of PABA
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