What is mhc - Study guides, Class notes & Summaries

what does immunological tolerance create ~~> random generation of repertoire of BCR and TCR production of self reactive specificities types of TCR recognition due to random TCR gene rearrangement ~~> - can't recognise self-MHC (die) - recognise self MHC and p from Ag in thymus (+ve then eliminated by -ve selection) - self MHC and p not in thymus (+ve selection) what is TCR survival and tolerance based on ~~> TCR affinity need a pop of cells with medium affinity to self MHC...

Combined Immunology HMX Exam with 100% Correct Answers 2024/2025. Individuals who are not identical twins differ in many genes that they do not inherit. This means individuals will have different proteins based on these different genes. These differences are called ______________________ - Correct Answer-polymorphisms In transplantation, if one person is a donor and another is a recipient, then there might be a difference in proteins between each person. So, when an organ is transplanted, t...

Which of the following would be a potential explanation for T-cell mediated autoimmune disease? correct answers Failure of apoptosis of self-recognizing T cells A 25-year-old woman with lupus has been taking a medication that inhibits the effect of CD4- secreted cytokines, specifically Tumor Necrosis Factor (TNF). She comes to her physician's office with a fever and a cough lasting for weeks. Based on her medical history, which of the following is this patient at the greatest risk of develop...

What are the external TLRs - TLR-5:Bacterial Flagellin TLR-4:Bacterial LPS TLR-3 recognizes? - Double stranded Viral RNA TLR-7 recognizes? - Single stranded Viral RNA TLR-5 recognizes? - bacterial flagellin TLR-4 recognizes? - Bacterial LPS Leukocytes in the order to action - 1. Neutrophils - Mass quantities 2. Monocytes 3.Lymphocytes - days later 2 cell type recognition - 1. NK - looking at your own cells 2. Macrophages - looking at pathogen directly Macrophages - use toll like recep...

ACHS Immunology Exam 1 Questions & Answers 2023/2024 What does MHC stand for? What does it to? - ANSWER-major histocompatibility complex; group of genes that code for proteins found on the surfaces of cells that help the immune system recognize foreign substances. Why is the MHC called a complex? - ANSWER-- It is enclosed by a cluster of closely associated genes within a long continuous stretch of chromosome -Located on human chromosome 6 3 classes of molecules in the MHC complex - A...

Foundations of Medicine – Immunology Exam With Verified Answers Pluripotent hemopoietic stem cell The precursor cell that is capable of giving rise to all blood cell lineages: Erythrocytes Platelets Granulocyte/monocyte (myeloid) Lymphocyte (lymphoid) Where does a mast cell come from? Unknown, but thought to originate in spleen, thymus, or lymph node How are mast cells different from other hematopoietic cells? Mast cells are fixed to tissues rather than circulating in...

ACAAI Review for the Allergy & Immunology Boards ALL CHAPTERS with Complete SolutionsACAAI Review for the Allergy & Immunology Boards ALL CHAPTERS with Complete SolutionsACAAI Review for the Allergy & Immunology Boards ALL CHAPTERS with Complete Solutions What is the hapten-carrier effect? - ANSWER-Small-molecule antigen requires covalent linkage to a larger carrier to stimulate adaptive immune response. The process is achieved in collaboration between hapten-specific B cells and carrier-specif...

Which proteins are encoded by complex II? - ️️each gene encodes 1 alpha chain and 1 beta chain (two letters, two gene products) - HLA-DP - HLP-DQ - HLP-DR In general, what is the process of antigen presentation? - ️️1. pathogen protein in a human cell 2. antigen processing by breakdown of protein 3. presentation of peptide by MHC molecule 4. recognition of antigen-MHC complex by TCR Why is the MHC necessary? - ️️For the activation of T cells What are the similarities and d...

Immunology Exam 2 Study UAMS MLT- MLS | Latest Update | 2024/2025 | Graded A+ 1st recognizable B cell Pro-B cell A Memory B cell: -Requires protein antigen -Located in secondary follicles -Long life span -On subsequent contact with antigen:•Ability to respond rapidly & with greater intensity A T-cell that has class I MHC and comes in contact with a peptide and has a weak recognition, what does it become? it becomes a mature CD8 T-cell A T-cell that has class II MHC and come...

Antibodies consist of ___________. - Two identical heavy chains and two identical light chains Regions of TCRs and BCRs that are particularly variable in their amino acid sequences are known for ____________. - Binding to antigen MHC molecules ____________. - Are recognized by T cells Based on your knowledge of MHC I and II, predict which cell type would be MOST likely not to express detectable MHC I? - Erythrocytes Which of the following would be LEAST likely to express MHC class II? - T ...