CMB2004 Lecture 07 Questions and Answer | Latest Update 2024/2025
4 views 0 purchase
Course
Cmb2004
Institution
Cmb2004
what does immunological tolerance create
~~> random generation of repertoire of BCR and TCR production of self
reactive specificities
types of TCR recognition due to random TCR gene rearrangement
~~> - can't recognise self-MHC (die)
- recognise self MHC and p from Ag in thymus (+ve then...
can respond to self MHC when peptides are derived from AG not present in
thymus
what happens to T cells that fail +ve selection
~~> further rearrangements of TCRalpha locus
produce different R
Autoimmune Regulator (AIRE)
~~> Txn factor
in tolerance induction
expression of tissue-specific Ag in thymus
deletes T cells recognising them
Deficiency of AIRE
~~> autoimmune syndrome
what happens to self reactive BCR
Master01 | September, 2024/2025 | Latest update
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ExamArsenal. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.79. You're not tied to anything after your purchase.
