usmle
Western Governors University
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(Updated Solution) USMLE Step 1 Rapid Review: Guaranteed A+ Guide
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abdominal pain, ascites, hepatomegaly 
(Ans- Budd-Chiari syndrome 
 
Familial hypercholesterolemia 
 (Ans- achilles tendon xanthoma 
 
adrenal hemorrhage, hypotension, DIC 
(Ans- Waterhouse-Friderichsen syndrome 
 
biochemistry of Marfan's syndrome 
(Ans- fibrillin defect 
 
posthepatic venous thrombosis 
 (Ans- Budd-Chiari syndrome 
 
Familial hypercholesterolemia biochemistry 
 (Ans- decrease in LDL receptor signaling 
 
Waterhouse-Friderichsen syndrome cause 
 (Ans- meningococcemia 
 
ara...
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(Updated) USMLE Step 3 Study Guide: Guaranteed A+ Guide Solution
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Pseudogout associations 
(Ans - hemochromatosis, hyperparathyroidism, acromegaly, hypothyroidism 
 
Gout crystals 
(Ans - negatively birefringent needles 
 
Pseudogout crystals 
(Ans - positively birefringent needles 
 
Vasculitis associated with chronic Hep B 
(Ans - polyarteritis nodosa 
 
Vasculitis associated with chronic Hep C 
(Ans - cryoglobulinemia 
 
Best blood test for polyarteritis nodosa 
(Ans - There is none. Get abdominal angiography first, then biopsy of muscle, skin, or sural ner...
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Biochemistry USMLE step 1: Updated Solution: Guaranteed A+ Guide Solution
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histones are rich in which 2 AA's 
(Ans- lysine & argenine 
 
Barr bodies (what, type of chromatin) 
(Ans- inactive X chromosomes 
heterochromatin (highly condensed, sterically inaccessible) 
 
less condensed, transcriptionally active, sterically accessible chromatin (Ans- euchromatin 
 
DNA methylation at CpG islands 
 (Ans- represses transcription 
 
"CpG Methylation makes DNA Mute" 
 
DNA methylation (what is methylated and why?) 
(Ans- template strand cytosine and adenine are methylate...
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(Solved ) USMLE Lysosomal Storage Diseases: Questions & Answers: Updated
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What is the deficient enzyme in Fabry's disease? 
(Ans- alpha-galactosidase A 
 
What is the accumulated substrate and inheritance in Fabry's disease? (Ans- ceramide trihexoside and XR 
 
What are the findings in fabry's disease? 
(Ans- peripheral neuropathy of hands/feet, angiokeratomas, cardiovascular /renal disease 
 
What is the deficient enzyme in Gaucher's disease? 
(Ans- Glucocerebrosidase 
 
What is the accumulated substrat
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(Answered) USMLE Step 1 UWorld High Yield Notes: Questions & Answers: Updated Solution
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What are the two major microtubular motor proteins? Which does anterograde axonal transport, which does retrograde axonal transport? (Ans- Kinesin, Dynein 
 
Kinesin: Anterograde 
Dynein: Retrograde` 
 
What do you think, immunologically speaking, when you see someone with recurrent Neisseria infections? 
(Ans- Inability to form the membrane attack (MAC) complex 
this is a common complement deficiency 
 
What is the defect in Chronic Granulomatous disease? What is the pathophysiology? 
(Ans- N...
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Solved) USMLE Genetics: Updated A + Guide Solution: Updated
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What are the three things a USMLE question about genetics will ask you to do using a pedigree? 
(Ans- Recognize a mode of inheritance 
Predict the recurrence risk of a disease, say in an unborn child 
Identify an OBLIGATE carrier for disease 
 
How do you determine the probability of an unborn child being affected by an AR trait when you know the father is a carrier and the mother has probability X of being a carrier? 
(Ans- Multiply the odds of the baby being affected IF the mother was a carr...
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USMLE step 3 - drug MOA (indications): Updated Solution
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Erythromycin 
(Ans- 50S ribosome, inhibits TRANSLOCATION (movement of tRNA-aa from acceptor site to peptidyl site) 
 
clindamycin, chloramphenicol 
 (Ans- 50 ribosome, inhibits PEPTIDYL TRANSFERASE (incorporation of new a.a.'s into growing strand) 
 
Linezolid 
 (Ans- 50S protein synthesis inhibitor 
 
tetracycline 
(Ans- 30S ribosome, blocks tRNA-aa from binding to ACCEPTOR SITE on mRNA 
 
aminoglycosides 
(Ans- 30S ribosome, blocks INITIATION of translation and induces PREMATURE TERMINATIO...
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USMLE step 3 Study Guide: Updated A+ Guide Solution
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Clues to ischemic disease 
(Ans- 
dull pain 
15-30 minutes 
occurs on exertion 
substernal 
radiates to jaw or left arm 
 
PE findings for ischemic chest pain 
(Ans- 
S3 (dilated LV) 
S4 (hypertrophic LV) 
holosystolic murmur (MR) 
JVD 
Rales (CHF) 
Edema 
Gen: distressed, SOB, clutching chest. 
 
MI: diagnostic testing: 
1. first test to do: 
2. if choosing between testing and treatment: 
3. first treatment to give: 
4. Other tests to do: 
5. most accurate test: 
(Ans- 
1. EKG 
2. tr...
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Endocrinology USMLE Step 1: Questions & Answers: Updated A+ Score Solutions
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what is the embryonal origin of the adrenal cortex? 
(Ans- mesoderm 
 
what is the embryonal origin of the adrenal medulla? what are the cells of the adrenal medulla called? 
 (Ans- neural crest; chromaffin cells 
 
T/F the chromaffin cells of the adrenal cortex are are considered preganglionic 
(Ans- false- postganglionic and ganglionic sympathetic 
 
what autonomic is the adrenal medulla innervated by? what are the NT? what are the receptors called? what kind of receptors are they? 
(Ans- s...
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