Advanced Pharmacology
Wayland Baptist University
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ADVANCED PHARMACOLOGY: NR 566 Week 1 Notes Ch. 21, 33, & 41 Chapter 21: Drugs Affecting the Endocrine System
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NR 566 Week 1 Notes Ch. 21, 33, & 41 
Chapter 21: Drugs Affecting the Endocrine System 
Pharmacokinetics 
 Absorption and Distribution 
o All oral bisphosphonates potentially cause esophagitis and gastric irritation 
o Absorption and bioavailability of oral doses are significantly reduced by the presence of food in 
the gut or other preparations containing divalent cations. 
o To enhance absorption, the patient takes the drug with 8 oz of water, No other food or drink 
should be ingested, and...
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