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Test Bank - Cellular and Molecular Immunology, 10th Edition (Abbas, 2022), Chapter 1-21 | All Chapters
Test Bank - Cellular and Molecular Immunology, 10th Edition (Abbas, 2022), Chapter 1-21 | All Chapters
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,DOWNLOADTHETestBankforCellularandMolecularImmunology10thEditionAbbas
Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10thEdition v
TestBank
Chapter2:CellsandTissuesoftheImmuneSystemMatching
V V V
Questions1-5
V
Match eachofthedescriptions in questions1-5with theappropriatename(A-M)ofananatomicfeature of
v V V V V V V V V V
lymphoidtissues.
V V
A. Periarteriolarlymphoidsheath V V
B. Thymicmedulla
C. Thymiccortex
D. Parafollicularcortexoflymphnode V V V V
E. Hematopoieticbonemarrow V V
F. Afferentlymphatic
G. Efferent lymphatic v
H. Marginalzone
I. Redpulpofspleen
J. Whitepulpofspleen
K. Epidermis
L. Dermis
M. Peyer’spatch
1. LocationofmostTlymphocytesin thespleen
V V v
ANS:A.Theperiarteriolarlymphoidsheathsurroundsthecentralarteriesinthespleenand istheT cell zone V V V
inthisorgan.
V V V
2. Vesselsthatdrain lymphawayfromalymphnode v v V
ANS:G.Efferentlymphaticvesselsdrainlymphawayfromlymphnodes;afferentvesselsdrain
V V V V V V V V V V V V
lymphintolymphnodes.
V V V V
3. SiteofleastmatureTcellprecursorsinthethymus
V V V
ANS: C.Bonemarrow–derivedTcell precursors first enterthe thymiccortex and migrate
V V V V V V V V V V V V
intothemedullaastheybecomemoremature.
V V V V V V V
4. LocationofLangerhanscells V V
ANS:K.Langerhanscellsaredendriticcellsintheepidermisoftheskinthatdevelopfromfetalmacrophages.
V V V V V V V V V V V V V V V V
Copyright © 2022 Elsevier Inc. All rights reserved.
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,DOWNLOADTHETestBankforCellularandMolecularImmunology10th
EditionAbbas
5. Lymphoid aggregateof themucosal immunesystem V v V
ANS: M. Peyer’s patches are B cell–rich lymphoid aggregates located in the submucosa of the
V V V V V V V V V V V V V V
smallintestine.
V
MultipleChoice V
6. Which ofthefollowingisthegenerative(primary)lymphoidorgan forTlymphocytes?
v V V V V V V V
A. Bonemarrow
B. Spleen
C. Lymphnode
D. Thymus
E. Tonsil
ANS: D. Generative (primary) lymphoid organs are the organs where lymphocytes first express
V V V V V V V V V V V V
antigen receptors and attain functional maturity. Although T cell precursors arise in the bone marrow,
V V V V V V V V V V V V V V V
these precursors migrate to the thymus, where maturation takes place. In contrast, B cells mature in the
V V V V V V V V V V V V V V V V V
bone marrow. Spleen, lymph node, and tonsil are secondary lymphoid organs populated by mature B
V V V V V V V V V V V V V V V
andTcells.
V V
7. Whichofthefollowingstatementsabouttissue-residentmacrophagesiscorrect?
V V V V V V V V V
A. Theyareallderivedfrombloodmonocytesthatentertissuesduringinfections V V V V V V
B. Manyofthesecellsfirstpopulatetissuesduringfetaldevelopment V V V V V V
C. Theydifferentiatefrom different kindsofepithelial cellsineachtissue V v V V V V V
D. Theyconstantlyrecirculatebetweendifferenttissues V V V V V
E. Theyareprofessionalantigen-presenting cellsthat activate naive Tcellsthat migrateinto V v v
tissues
V
ANS: B. Many tissue-resident macrophages are derived from fetal yolk sac and fetal liver precursors
V V V V V V V V V V V V V V
and establish residence in the different tissues during fetal development. Other tissue- resident
V V V V V V V V V V V V V
macrophages are derived from bone marrow–derived blood monocytes that enter tissues under
V V V V V V V V V V V V
normal conditions or during infections. Epithelial cells do not differentiate into macrophages. Once in
V V V V V V V V V V V V V V
the tissue, tissue-resident macrophages cells do not leave to recirculate. Naive T cells do not usually
V V V V V V V V V V V V V V V V
enter non-lymphoid tissues, and tissue-resident macrophages have no role in presenting antigen to
V V V V V V V V V V V V V
naiveTcells.
V V V
8. Which typeofleukocyteisthe mostabundantintheblood of a healthyadult? V V V V V V v V
A. Monocytes
B. Blymphocytes
C. Tlymphocytes
D. Polymorphonuclearleukocytes V
E. Basophils
Copyright © 2022 Elsevier Inc. All rights reserved. V n n n n n V
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EditionAbbas
ANS: D. Polymorphonuclear leukocytes (or neutrophils) are the most abundant blood leukocyte (~
V V V V V V V V V V V V
4,000/mm3),abouttwicethenumberofBandTlymphocytescombined.
V V V V V V V V V V v V
9. Whichofthefollowingisafeatureoffibroblasticreticularcells(FRCs)?
V V V V V V V V
A. Theylinethelumensoflymphaticsenteringlymphnodes V V V
B. Theyarederivedfromhematopoieticprecursors V V V
C. TheyplayacriticalroleinestablishingwherelymphocytesarelocatedinlymphnodesV V V V V V V V V V
D. TheysecretecytokinesthatstimulateTcellproliferation V V V
E. Theyarephagocyticcellsofinnateimmunitythatkillmicrobes V V V V
ANS: C. FRCs are mesenchymal-derived (not haematopoietically-derived) cells with properties of
V V V V V V V V V V
muscle and fibroblast (myofibroblasts) that drive formation of secondary lymphoid organs during
V V V V V V V V V V V V
embryonic development and contribute to the anatomic segregation and movement of lymphocytes and
V V V V V V V V V V V V V
dendritic cells in secondary lymphoid organs. They are not phagocytic, have no direct antimicrobial
V V V V V V V V V V V V V V
effectorfunctions, donotsecrete IL-2orotherTcell growth factors, and donot linelumensoflymphatics.
V V V V V V V V V V V V V V V V V V V
10. Which type of cell is most important in capturing protein antigens of microbes
V V V V V V V V V V V V
thatenterthroughepithelialbarriersandpresentingthemtonaiveTcellsinsecondarylymphoid
V V V V V V V V V V V V
organs?
V
A. Classicaldendriticcells V V
B. Plasmacytoid dendriticcells V V
C. Plasmacells
D. Macrophages
E. Folliculardendriticcells V
ANS: A. Classical (or conventional) dendritic cells (DCs) are the main cell type that brings microbial
V V V V V V V V V V V V V V V
antigens from infected tissues into draining lymph nodes and presents peptides derived from these
V V V V V V V V V V V V V V
antigens to naive T cells that circulate though the lymph nodes. Plasmacytoid DCs secrete type 1
V V V V V V V V V V V V V V V V
interferons in response to viral infection. Plasma cells are antibody-secreting cells derived from B cells
V V V V V V V V V V V V V V V
and do not present antigen to T cells. Macrophages can present antigen to effector T cells, but they are
V V V V V V V V V V V V V V V V V V V
not efficient activators of naive T cells. Follicular dendritic cells displayantigenstoBcellsonlymphoid
V V V V V V V V V V V V V V V V V
follicles.
V
Copyright © 2022 Elsevier Inc. All rights reserved. V n n n n n V
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