Sputum Bowl – Pharm UPDATED
ACTUAL Questions and CORRECT
Answers
How do you calculate the volume of disribution, VD? - CORRECT ANSWER✔✔- VD =
drug amt put into body divided by concentration of drug in blood (mg/mg/L)
What do you call a simple valveless extension device that puts distance between an MDI and
the patient's mouth? - CORRECT ANSWER✔✔- A "spacer"
What is the phase of pharmacology which describes the way by which a drug dose is made
available to the body? - CORRECT ANSWER✔✔- The pharmaceutical phase
The "United States Pharmacopeia" undergoes revision every how many years? - CORRECT
ANSWER✔✔- 5 years
What phase of drug action describes the time course and disposition of a drug in the body,
based on its absorption, distribution, metabolism, and elimination? - CORRECT
ANSWER✔✔- The pharmacokinetic phase
How does a catecholamine nucleus differ from a resorcinol? - CORRECT ANSWER✔✔-
The hydroxyl attachment at the #4 carbon is shifted to #5 carbon; metaproterenol (Metuprel,
Alupent) and terbutaline (Brethine, Brethaine, Bricanyl) are both resorcinols
What is the mechanism of action of class III antiarrhythmic agents? - CORRECT
ANSWER✔✔- Prolong phase 3 > lengthen refractory period (ex: Bretylium tosylate)
What drug is the most popular expectorant? - CORRECT ANSWER✔✔- Guaifenesin
(formerly known as glyceryl guaiacolate, guaicol is a catechol)
How much pirbuterol is released from the MDI canister per puff? - CORRECT
ANSWER✔✔- 0.2 mg/puff or 200ugm (300 inhalations/canister, produced by 3M
Pharmaceuticals --has a peridine ring instead of benzene ring, onset of 5-8 min, peak effect
30 min, duration 5 hrs)
,What is the active ingredient of the nasal sprat known as Afrin? - CORRECT ANSWER✔✔-
Oxymetazoline (0.05%)
What is the name of the part of a prescription that contains the name and amount of the drug
being prescribed? - CORRECT ANSWER✔✔- Inscription
What is the now accepted use of the drug called alpha-1-antitrypsin? - CORRECT
ANSWER✔✔- Supplementation therapy for alpha-1-antitrypsin deficiency
Specifically, what is the mechanism of action of indomethocin? - CORRECT ANSWER✔✔-
Inhibitor of cyclo-oxygenase
The pro-drug, bitolterol, is metabolized by what enzyme? - CORRECT ANSWER✔✔- Ester
Name the two most likely candidates as the transmitter chemicals in the non-adrenergic, non-
cholinergic fibers? - CORRECT ANSWER✔✔- VIP (vasoactive intestinal peptide), PHM
(peptide histidine methionine)
At what serum theophylline concentration does the pulse rate increase? - CORRECT
ANSWER✔✔- 15 ug/ml (electrophysiologic studies showed acceleration of intracardiac
conduction at 15 ug/ml and this could be instrumental in provoking supraventricular
arrhythmias at higher toxic levels)
By what mechanism do unmyelinated sensory nerve ending of the c-fiber type release
"tachykinins" such as substance P? - CORRECT ANSWER✔✔- Axonal reflex
In line MDI's should not be used in mechanically ventilated infants if the tidal volume is less
than what amount? - CORRECT ANSWER✔✔- 100 ml
Other than progesterone and doxapram, name two other drugs used as respiratory
stimulants.Other than progesterone and doxapram, name two other drugs used as respiratory
stimulants. - CORRECT ANSWER✔✔- Almitrine bismesylate, Protriptyline, Theophylline,
Acetazolamide, Naloxone
, What term is defined by the following words? "Any chemical that alters the organism
functions or processes" - CORRECT ANSWER✔✔- Drug
Define the term "pharmacognosy". - CORRECT ANSWER✔✔- The identification of
sources of drugs from plants and animals (or microbes)
What are the six parts of a prescription? - CORRECT ANSWER✔✔- Patient name, address,
and date; superscription, inscription, subscription, transcription, name of prescriber
What do you call any chemical that alters an organism's functions or processes? - CORRECT
ANSWER✔✔- A drug
What drug, other than pentamadine, is effective against P. carinii? - CORRECT
ANSWER✔✔- Trimethoprim-sulfamethoxazole
How many tons of chloroflourocarbons are used each year in metered dose inhalers? -
CORRECT ANSWER✔✔- 4,500 tons (0.4% to 0.5% of annual production)
If you are administering ribavirin, what device should be used and what dose should be
given? - CORRECT ANSWER✔✔- SPAG nebulizer, 6gm/300ml (2%), 12-18 hrs/day, 3-7
days
Name four ingredients contained in a metered dose inhaler. - CORRECT ANSWER✔✔- The
drug, surfactant, chloroflourocarbons (F11, F12, F13, F14), flavoring agents, preservatives
Which of the immunoglobins is referred to as "cytophilic antibody"? - CORRECT
ANSWER✔✔- IgE
What group of drugs is known to have a "gastropulmonary mucokinetic vagal" reflex action?
- CORRECT ANSWER✔✔- Iodides (also guaifenesin - glyceryl guaiacolate; SSKI contains
1000mg/ml, so a dosage of 10 drops QID would deliver 4g. Complications include: iodine
sensitivity in the form of acneiform rash, and hypothyroidism in 5% of patients)
