100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
NMTCB PET certification Review UPDATED Actual Questions and CORRECT Answers $9.49   Add to cart

Exam (elaborations)

NMTCB PET certification Review UPDATED Actual Questions and CORRECT Answers

 11 views  0 purchase
  • Course
  • NMTCB
  • Institution
  • NMTCB

NMTCB PET certification Review UPDATED Actual Questions and CORRECT Answers Rb-82 Genertaor Alert Level - CORRECT ANSWER- 14L of eleute volume reached, or Sr-82 level 0.002uCi/mCi of Rb-82, or Sr-85 level 0.02uCi/mCi of Rb-82 Actions for Rb82 Generator Alert Level - CORRECT ANSWER- Test afte...

[Show more]

Preview 3 out of 28  pages

  • October 4, 2024
  • 28
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NMTCB
  • NMTCB
avatar-seller
MGRADES
NMTCB PET certification Review
UPDATED Actual Questions and
CORRECT Answers
Rb-82 Genertaor Alert Level - CORRECT ANSWER✔✔- 14L of eleute volume reached, or
Sr-82 level 0.002uCi/mCi of Rb-82, or Sr-85 level 0.02uCi/mCi of Rb-82


Actions for Rb82 Generator Alert Level - CORRECT ANSWER✔✔- Test after every 750
mL has passed through generator


Stop using Rb-82 generator if - CORRECT ANSWER✔✔- 17L of eleute volume reached, or
42 days post calibration date, or Sr82 levenis 0.01uCi/mCi of Rb82, or Sr85 level reaches
0.1uCi/mCi of Rb82


Cyclotron produced isotopes and half-life - CORRECT ANSWER✔✔- C11, 20.3 min; N13
9.97 min; O15 2.03 min; F18, 109.7 min


Advantages of negative ion cyclotrons - CORRECT ANSWER✔✔- 1) less nuclear
activation of cyl potion cavity and surroundings, 2) can self-focus beam of particles, 3) can
irradiate 2 targets at once


Isotopes produces by negative ion cyclotrons - CORRECT ANSWER✔✔- C, N, O =
metabolites


Reaction for chemical labeling of F18-FDG - CORRECT ANSWER✔✔- Nucleophilic
substitution


Chemical reaction of FDG - CORRECT ANSWER✔✔- Electron rich group of atoms change
place on molecule with a positively charged leaving group


Precursor molecule for FDG - CORRECT ANSWER✔✔- Mannose triflate

,Chem formula of FDG - CORRECT ANSWER✔✔- 2-deoxy-2-[18F]fluoro-D-glucose.
(Fludeoxyglucose F-18)


Intermediate step in FDG synthesis - CORRECT ANSWER✔✔- Alkaline hydrolysis of 4
acetyl groups by replacing with OH


Size filter used after purification - CORRECT ANSWER✔✔- 0.22 um



FDA ref for PET pharma production - CORRECT ANSWER✔✔- General chapter 823



FDG QA appearance - CORRECT ANSWER✔✔- Colorless liquid



FDG QA radiochemical identity - CORRECT ANSWER✔✔- Thin-layer chromatography Rf
value to reference standard


FDG QARadionuclide identity - CORRECT ANSWER✔✔- Half-life 105 and 115 minutes



FDG QA bacterial endotoxins test - CORRECT ANSWER✔✔- LAL (Limulus amebocyte
lysate) <175 USP endotoxins units per max volume injection; endotoxins< 17.5 EU


FDG QC pH - CORRECT ANSWER✔✔- Between 4.5 to 7.5



FDG QA Radiochemical purity - CORRECT ANSWER✔✔- Thin-layered chromatography
radioactive Rf should be not less than 90% of total radioactivity of chromatography plate


FDG QC Radionuclideic purity - CORRECT ANSWER✔✔- should be >99.5% of
radionuclidie specified. tested using multi-channel analyzer with peaks at 0.511 and 1.022
MeV


FDG QC chemical purity - CORRECT ANSWER✔✔- testing depends upon synthesis
method used to create FDG

, Kryptofix 222 - CORRECT ANSWER✔✔- FDG QC chemical purity test - thin-layer paper
chromatography spot test. 50 ug/mL and FDG solution must demonstrate a less intense
response than standard


2-Chloro-2-deoxy-D-glucose - CORRECT ANSWER✔✔- FDG QC chemical purity test
used if hydrolysis step was performed with hydrochloric acid. Use high-performance liquid
chromatography using an electrochemical detector. Mus not have more than 1 mg CLDG: 2-
deoxy-2-D-glucose


FDG QC Residual solvents - CORRECT ANSWER✔✔- solvents can be in FDG from
cleaning or synthesis solutions. solutions may contain acetonitrle, ether anddehydrated
alcohol. no more 0.04% acetonitrle, and less than 0.5% of ether or ethanol


FDG QC Sterility - CORRECT ANSWER✔✔- not performed before dosing due to need of
14 days to perform. Regulations require final produce to be placed in soy broth mixture with
a thioglycollate growth media for 30 hrs. look for observable bacteria


FDG QC Filter membrane integerity - CORRECT ANSWER✔✔- final sterility filter used at
end of manufacturing process. Filter must remain intact as pressure increased to 50 psi
(bubble point test)


FDG synthesis room requirements - CORRECT ANSWER✔✔- room: cGMP, ISO class 5
clean room air hood, 21 CFR 212 for manufacturing of IV drugs


which radiouclides are possible radioactive contaminates in eluent of Rb82 generators -
CORRECT ANSWER✔✔- Sr82 and Dr85



negative ion PET cyclotrons accelerate which partiles - CORRECT ANSWER✔✔-
negatively charged hydrogen atoms


chemical method used to label F18 to glucose - CORRECT ANSWER✔✔- nucleophilic
substitution


The least amount of energy needed by bombarding particles used for nuclear reactions
occurring within a cycltron - CORRECT ANSWER✔✔- 8 Mev

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller MGRADES. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $9.49. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

71184 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$9.49
  • (0)
  Add to cart