Polymerise - Study guides, Class notes & Summaries

Sickle cell anaemia learning card Sickle cell syndrome Hereditary hemoglobinopathy Homozygous sickle cell anaemia (HbSS, autosomal recessive) is the most common variant Occurs in African and East Meditarranean populations (mosquito) Point mutation of the beta chain of hemoglobin leads to a substitution of glutamic acid by valine (changing the structure and properties) Abnormal hemoglobin polymerizes when deoxygenated, resulting in sickle shaped erythrocytes (cause vascular occlusio...

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