Ngr 6172 stuvia - Study guides, Class notes & Summaries

Aspirin- MOA - Answer Binds irreversibly to cyclooxyrgenase-1 and 2 (COX 1 and 2) Decrease prostaglandin and thromboxane A2 production Plavix (clopidogrel) -MOA - Answer Produg- irreversibly inhibits P2Y12 ADP-mediated platelet activation and aggregation Boxed warning of Plavix - Answer conversion to active metabolite require (CYP 450 2C19) Poor metabolizers - higher CV events Plavix- avoid to take with what - Answer 2c19 inhibitors (omeprazole, esomeprazole) increased bleed pos...

MOA for insulin - Answer Transports glucose across cell membrane MOA for sulfonurias (glipizide, Glucotrol) - Answer Stimulates insulin secretion MOA for biguanides (metformin) - Answer Reduce hepatic glucose production MOA for Thiazolidinediones (Actos) - Answer Increases peripheral insulin sensitivity MOA for Secretagogues or meglitinides (nateglinide, prandin) - Answer short-term beta cell timulation MOA for alpha-glucosidase inhibitors (acarbose, Precose) - Answer Prevent brea...