Malignant hypert Study guides, Class notes & Summaries
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Malignant hyperthermia | Questions with 100 % correct answers | Verified
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What is Malignant hyperthermia? - -inherited disorder of skeletal muscle 
-triggered in susceptible humans or animals by inhalation agents or Sch 
Name the 4 characteristics MH. - -hypermetabolism 
-skeletal muscle damage 
-hyperthermia 
-death ( if left untreated) 
T/F. A MH susceptible person often will not trigger with every exposure. - true 
Patients with trismus have ____ incidence of positive MH testing. - higher 
T/F. Unusual before age 3 or after age 60. - true 
T/F. Males affected more ...
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Malignant Hyperthermia | Questions and Answers(A+ Solution guide)
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What is Malignant Hyperthermia (MH) and what is it triggered by? - MH is characterized by a 
HYPERMETABOLIC state and SKELETAL MUSCLE RIGIDITY 
It is triggered by exposure to INHALATIONAL agents or SUCCINYLCHOLINE in susceptible individuals 
What is the pathophysiology of MH? - Pathophysiology of MH: 
- numerous mutations on the Ryanodine (Ryr1) and alpha 1 subunit of Ca+ receptor 
- impairment of Ca+ reuptake by the sarcoplasmic reticulum when exposed to trigger agents 
What is the incidence of...
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Malignant Hyperthermia | Questions and Answers(A+ Solution guide)
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What is malignant hyperthermia (MHS)? - This is a complex genetic disorder of skeletal muscle 
typically manifesting clinically as a hypermetabolic crisis when a susceptible individual receives a 
halogenated inhalational anesthetic agent or succinylcholine 
-They have skeletal muscle receptor abnormalities that allow excessive myoplasmic calcium to 
accumulate in the presence of certain anesthetic triggering agents. This excessive Ca lead to sustained 
muscle contraction 
How is malignant hyper...
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Malignant Hyperthermia Bundled exams everything you need to pass is here
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Malignant Hyperthermia Bundled exams everything you need to pass is here
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Malignant hyperthermia Questions and Answers;(perfect guide for your final)
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Overview - Rare inherited disorder in which a severe life-threatening reaction occurs due to inhaled 
anesthesia gases or a muscle relaxant called succinylcholine 
Hypermetabolic state that results in a rapid rise in body temperature and severe muscle contraction 
Possibly resulting in death if untreated 
Overview-Pathophysiology - A defect in calcium regulation results from a triggering anesthetic agent 
due to an inherited disorder of the musculoskeletal system. This calcium regulation defect ...
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Malignant Hyperthermia exam Already Passed!!
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What is malignant hyperthermia? - It is a rare, life-threatening, hypermetabolic skeletal muscle 
disorder. 
How does malignant hyperthermia occur? - Triggering agents induce significantly increased calcium 
concentrations in the skeletal muscle cells. Sustained muscle contraction occurs. Energy-dependent 
calcium channels try to remove the excess calcium which increases the metabolism of the skeletal 
muscles. The increased metabolism depletes ATP stores and causes lactic acidosis. The acidosis...
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Malignant Hyperthermia | Questions with 100 % correct answers | Verified
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Arrhythmia - Irregular heartbeat. Improper beating of the heart. 
Hypercapnia - Excessive carbon dioxide in the bloodstream 
Hyperkalemia - Condition in which there is too much potassium in the blood. 
Metabolic Acidosis - A pH imbalance in which the body has accumulated too much acid 
Myoglobinuria - Muscle protein in the urine. Usually associated with rhabdomyolysis or muscle 
destruction. 
Cola colored urine. 
Rhabdomyolysis - Condition in which skeletal muscle is broken down, releasing muscl...
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Malignant hyperthermia | Questions with 100 % correct answers | Verified
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Malignant hyperthermia - is a life-threatening familial hypermetabolic disorder of skeletal muscle 
that can be precipitated by specific anesthetic agents. 
characteristics of MH - tachycardia, tachypnea, hyperthermia, generalized muscle rigidity, acidosis, 
and increasing ETCO2 levels. 
how fast does the temperature increase with MH? - Rapid increase in temperature by as mush as 1o 
C every 5 mins. 
how does acidosis result from MH? - is a result of increased skeletal muscle metabolism that may...
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malignant hyperthermia | Questions and Answers(A+ Solution guide)
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What is the incidence of malignant hyperthermia in children? Adults? What is the mortality rate for 
malignant hyperthermia? - The incidence of malignant hyperthermia is 1 in 15,000 anesthetics in 
children and 1 in 50,000 in adults, The mortality rate is 10%. 
What are eleven clinical manifestations of malignant hyperthermia? - (1) Hypercarbia, (2) 
tachycardia, (3) tachypnea, (4) hyperthermia, (5) hypertension, (6) cardiac dysrhythmias, (7)acidosis 
(metabolic), (8) hyperkalemia, (9) skeletal ...
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Malignant Hyperthermia exam Already Passed!!
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Malignant hyperthermia triggers - Succinylcholine 
Volatile anesthetics 
Disease associated with malignant hyperthermia - Central core disease 
Duchenne muscular dystrophy 
Myotonic dystrophy 
Osteogenesis imperfecta 
Myelomeningocele 
Strabismus 
Signs/symptoms of malignant hyperthermia (also name the most sensitive, specific and earliest) - 1) 
Tachycardia (earliest) 
2) Increased ETCO2 despite adequate ventilation (most sensitive/specific) 
3) Rigidity 
4) Elevated temperature 
5) Acidosis 
6...
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