Inhibits dhf reductase - Study guides, Class notes & Summaries

FUNDAMENTALS OF CHEMOTHERAPY IMMUNOTHERAPY STUDY GUIDE EXAM WITH CORRECT AND VERRIFIED ANSWERS Alkylating Agents - CORRECT ANSWER-*MOA* -Inactive until metabolized by the microsomal P450 system -Metabolism forms highly reactive electrophils that react with neutrophiic groups crosslinking DNA and interfering with its function *Classical* = carmustine, cyclophosphamide, mechlorethamine *Non-Classical* = procarbazine, dacarbazine, temazolamide, bendamustine Cyclophosphamide - CORRECT ...

FUNDAMENTALS OF CHEMOTHERAPY IMMUNOTHERAPY STUDY GUIDE EXAM WITH CORRECT AND VERRIFIED ANSWERS Alkylating Agents - CORRECT ANSWER-*MOA* -Inactive until metabolized by the microsomal P450 system -Metabolism forms highly reactive electrophils that react with neutrophiic groups crosslinking DNA and interfering with its function *Classical* = carmustine, cyclophosphamide, mechlorethamine *Non-Classical* = procarbazine, dacarbazine, temazolamide, bendamustine Cyclophosphamide - CORRECT ...

Biochemistry USMLE step 1 questions correctly 2023histones are rich in which 2 AA's lysine & argenine Barr bodies (what, type of chromatin) inactive X chromosomes heterochromatin (highly condensed, sterically inaccessible) less condensed, transcriptionally active, sterically accessible chromatin euchromatin DNA methylation at CpG islands represses transcription "CpG Methylation makes DNA Mute" DNA methylation (what is methylated and why?) template strand c...

Azathioprine/6-MP: MOA, use - Answer Purine analog. Decrease purine synthesis. Activated by HGPRT Note: Azathioprine is metabolized to 6-MP Preventing organ rejection, rheumatoid arthritis, IBD, SLE; used to wean patients off steroids in chronic disease and to treat steroid-refractory chronic disease. Capecitabine - Answer pyrimidine analog, 5-FU prodrug Azathioprine/6-MP: Side effects - Answer 1. Myelosuppression-pancytopenia 2. GI/liver 3. *Increased toxicity with allopurinol/fubux...

USMLE Step 2 CK-Final Exam Questions and Answers Well Graded A+ steroids - CORRECT ANSWER-inhibit IL-1 production methotrexate - CORRECT ANSWER-folic acid antagonist, inhibits DHF reductase, S-phase specific, inhibits DNA synthesis cyclosporine - CORRECT ANSWER-calcineurin inhibitor; inhibits IL-2 production; nephrotoxic, gum hypertrophy, hursutism tacrolimus (FK506) - CORRECT ANSWER-calcineurin inhibitor; inhibits signaling thru T cell receptor mycophenylate mofeil - CORRECT ANSWER-preven...

Tx for trichomoniasis - ANSWER single-dose PO metronidazole or TINIDAZOLE for pt and partner(s) grayish-white vaginal discharge vs. yellow-green, frothy vaginal discharge - ANSWER grayish-white = bacterial vaginosis yellow-green, frothy = trichomoniasis If not managed appropriately, TSS can lead to death by what mechanism? - ANSWER ARDS (most common), or severe hypotension or hemorrhage 2º to DIC. Dx: 23 yo F present w/ vomiting, watery diarrhea, T 103F, and and desquamating rash. Blo...

Alkylating Agents MOA -Inactive until metabolized by the microsomal P450 system -Metabolism forms highly reactive electrophils that react with neutrophiic groups cross-linking DNA and interfering with its function Classical = carmustine, cyclophosphamide, mechlorethamine Non-Classical = procarbazine, dacarbazine, temazolamide, bendamustine Cyclophosphamide -Classical alkylating agent Toxicity - bone marrow suppression (days 8-14), cystitis, cardiac toxicity (high doses), immunosupp...

Study guide test 2 Strategies of nucleotide synthesis: precursors, when is ribose added, how is ribose activated and added, what are first purines and pyrimidines made, how are the various forms of THF made and/or interconverted, regulation of purine synthesis (where are committed steps), how is a balance between AMP and GMP achieved, how do folic acid antagonists impair purine synthesis. • Pyrimidines: base is made before adding the ribose sugar • Purines: ribose is already present  suga...

CHEMOTHERAPY Cell Cycle Specific Agents • Antimetabolites • Bleomycin • Podophyllin Alkaloids • Plant Alkaloids Cell Cycl e Non-Specific Agents • Alkylating Agents • Antibiotics • Cisplatin • Nitrosoureas Alkylating Agents Nitrogen Mustards Ethylenimines Alkyl Sulfonates Nitrosoureas Cyclophosphamide Thiotepa Busulfan Carmustine Alkylating Agents Mechanism of Action • Alkylate within DNA at the N7 position of guanine • Resulting in miscoding through abnormal base- pairing wit...