Biochemistry usmle step - Study guides, Class notes & Summaries
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biochemistry usmle step 1 questions and answers
- Exam (elaborations) • 69 pages • 2023
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. Determine the number of ATP molecules, which are formed in Krebs cycle at the 
conversion of isocitric acid to fumaric acid (I) and to succinyl CoA (II) respectively: 
A) I -7,0; II - 5,5 
B) I - 5; II - 3,5 
C) I - 6,5; II - 4,5 
D) I - 7,5; II - 5 
E) I - 7; II - 3 
2. In which stages of citric acid cycle is CO2 formed? 
1) Izocitrate - α-Ketoglutarate 
2) Succinate - Fumarate 
3) α-Ketoglutarate -Succinil-CoA 
4) Fumarate – Malate 
5) Malate –Oxaloacetate 
A) 1,3 
B) 2,4 
C) 1,4 
D) 3...
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Biochemistry USMLE Step 1 questions and answers
- Exam (elaborations) • 22 pages • 2023
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Achondroplasia involves what defect? – 
Cell-signaling defect of fibroblast growth factor (FGF) receptor 3 
Marfan's syndrome involves a mutation in what? – 
Fibrillin gene 
Xanthine, hypoxanthine and uric acid are all what type of base? – 
Purine 
What is the rate limiting step in Purine de novo synthesis? – 
PRPP step via glutamin PRPP amidotranferase 
PRPP amidotransferase inhibited by what downstream products in 
purine synthesis? – 
IMP, GMP, AMP and puring analogs Allopurinola a...
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First Aid USMLE Step 1: Biochemistry | Questions and answers | 2024/25
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First Aid USMLE Step 1: Biochemistry | Questions and answers | 2024/25
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Biochemistry USMLE Step 1 questions and answers 2022/2023
- Exam (elaborations) • 22 pages • 2023
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Biochemistry USMLE Step 1 
Achondroplasia involves what defect? – 
Cell-signaling defect of fibroblast growth factor (FGF) receptor 3 
Marfan's syndrome involves a mutation in what? – 
Fibrillin gene 
Xanthine, hypoxanthine and uric acid are all what type of base? – 
Purine 
What is the rate limiting step in Purine de novo synthesis? – 
PRPP step via glutamin PRPP amidotranferase 
PRPP amidotransferase inhibited by what downstream products in 
purine synthesis? – 
IMP, GMP, AMP and pu...
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Biochemistry usmle step 1 2023 questions and answers
- Exam (elaborations) • 69 pages • 2023
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1. Determine the number of ATP molecules, which are formed in Krebs cycle at the 
conversion of isocitric acid to fumaric acid (I) and to succinyl CoA (II) respectively: 
A) I -7,0; II - 5,5 
B) I - 5; II - 3,5 
C) I - 6,5; II - 4,5 
D) I - 7,5; II - 5 
E) I - 7; II - 3 
2. In which stages of citric acid cycle is CO2 formed? 
1) Izocitrate - α-Ketoglutarate 
2) Succinate - Fumarate 
3) α-Ketoglutarate -Succinil-CoA 
4) Fumarate – Malate 
5) Malate –Oxaloacetate 
A) 1,3 
B) 2,4 
C) 1,4 
D) ...
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Biochemistry USMLE Step 1: Questions & Answers: Latest Updated A+ Solution
- Exam (elaborations) • 22 pages • 2023
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Achondroplasia involves what defect? 
(Ans- Cell-signaling defect of fibroblast growth factor (FGF) receptor 3 
 
Marfan's syndrome involves a mutation in what? 
(Ans- Fibrillin gene 
 
Nucleoside + phosphate= ? 
(Ans- Nucleotide 
 
Adenine and Guanine are in what type of nucleic acid? 
 (Ans- Purines 
 
Cytosine, Uracil and Thyamine arein what kind of nucleic acid? 
 (Ans- Pyrimidines 
 
Xanthine, hypoxanthine and uric acid are all what type of base? 
 (Ans- Purine 
 
How many hydrogen bond...
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USMLE STEP 1 RAPID REVIEW EXAM 2024 WITH 100% CORRECT ANSWERS
- Exam (elaborations) • 61 pages • 2024
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USMLE STEP 1 RAPID REVIEW EXAM 2024 WITH 100% CORRECT ANSWERS 
 
abdominal pain, ascites, hepatomegaly - correct answer Budd-Chiari syndrome 
 
Familial hypercholesterolemia - correct answer achilles tendon xanthoma 
 
adrenal hemorrhage, hypotension, DIC - correct answer Waterhouse-Friderichsen syndrome 
 
biochemistry of Marfan's syndrome - correct answer fibrillin defect 
 
posthepatic venous thrombosis - correct answer Budd-Chiari syndrome 
 
Familial hypercholesterolemia biochemistry - cor...
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Biochemistry USMLE step 1 questions correctly 2023
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Biochemistry USMLE step 1 questions correctly 2023histones are rich in which 2 AA's 
lysine & argenine 
 
 
 
Barr bodies (what, type of chromatin) 
inactive X chromosomes 
heterochromatin (highly condensed, sterically inaccessible) 
 
 
 
less condensed, transcriptionally active, sterically accessible chromatin 
euchromatin 
 
 
 
DNA methylation at CpG islands 
represses transcription 
 
"CpG Methylation makes DNA Mute" 
 
 
 
DNA methylation (what is methylated and why?) 
template strand c...
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First Aid USMLE Step 1: Biochemistry questions with complete solution 2023.2024
- Exam (elaborations) • 57 pages • 2023
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First Aid USMLE Step 1: Biochemistry questions with complete solution 2023.2024
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Biochemistry USMLE step 1 Questions and Answers 100% Correct
- Exam (elaborations) • 75 pages • 2024
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"elfin" facies, ID, hypercalcemia (↑ Vit. D sensitivity), verbal & musical ability, extreme 
friendlinessWilliams syndrome 
"mewing," microcephaly, ID, VSDcri-du-chat syndrome 
(Debranching enzyme) 
(Myophosphoeylase) 
↑ glycogen in muscle→ painful muscle cramps, myoglobinuria (red urine) with strenuous 
exercise, arrhythmia 
normal blood glucoseGlycogen Storage Disease type V (McArdle) 
↑ HDL in a very unhealthy personEtOH → ↑ HDL synthesis 
↑ nuchal translucency and hypoplast...
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