Analgesic opioid agonists - Study guides, Class notes & Summaries

Opioid PharmacologyOpioid receptor subtypes - correct answer Mu, kappa, delta, (n=nociceptin) Mu, kappa & delta are G-i coupled GCPRs Mu is the predominant receptor Delta, kappa contribute to analgesia at *spinal level* Opioid receptor MOA - correct answer G-i coupled GCPRs - inhibition of AC 1) decrease in VG Ca2+ current (decrease NT release -->analgesic effect) 2) increased K+ conductance --> membrane hyperpolarization Distribution of opioid receptors in CNS, PNS - correct ...

NR 565 NR565 Advanced Pharmacology Midterm Exam Questions with Accurate Responses NR 565 NR565 Advanced Pharmacology Midterm Exam Questions with Accurate Responses During what trimester is a pregnant woman most at risk for adverse drug reactions with potential long term consequences? 1st trimester (fetus most at risk d/t rapid growth) What is BEERS criteria? Recommendations of medications inappropriate for elderly (65 and older), prescriber ultimately decides What is the CYP450 (cytoch...

half life Half-life (t½) is an important pharmacokinetic measurement. The metabolic half-life of a drug in vivo is the time taken for its concentration in plasma to decline to half its original level. Half-life refers to the duration of action of a drug and depends upon how quickly the drug is eliminated from the plasma. The clearance and distribution of a drug from the plasma are therefore important parameters for the determination of its half-life. B max The maximum amount of drug or radio...

Alfaxalone - correct answer -IV anesthetic for dogs/cats, extra-label IM sedation for cats/small dogs (not large dogs because larger amount needed), no analgesia -res depression -- muscle tremors/hyperreactivity when alone -neuroactive steroid molecule Amlodipine Besylate PO - correct answer -Ca channel blocker (inhibits voltage-gated Ca channels in cardiac & vascular smooth muscle) -txt of systemic arterial hypertension -Caution using with: heart disease and hepatic dysfunction Apom...

MPP Exam Questions With 100% Correct Answers Understand the basic effects of nAChR ganglionic antagonists (which are no longer used) - Answer-Specifically block NAChR in the ganglia Hexamethonium (No CNS) Mecamylamine (Yes CNS) Effects are the opposite of the predominant tone (either symp or para sym effects) Effects of nAChR ganglionic antagonists in the arterioles, heart and GI -Answer-always opposite of predominant tone Arterioles: hypotention/ postural hypotention Heart: tachycardia...

What are analgesic drugs? Correct Answer Pain killers that relieve pain without causing loss of consciousness. What are the 2 different class of analgesics? Correct Answer opioids analgesics and adjuvant analgesics What factors changes a person's perception of pain? Correct Answer Varies by attitude, environment, culture, ethnicity Past experience, anxiety, past experience, gender, general mental health A patient with bone cancer tells the nurse that he is in pain. The nurse knows tha...

Pain Assessment and Nursing Management Exam 203 Questions with Verified Answers Define pain - CORRECT ANSWER An unpleasant sensory or emotional experience Associated with actual or potential tissue damage Or described in terms of such damage (International Association for the Study of Pain) whatever the person says it is, whenever the person says it is - McCaffery complex, multidimensional experience that can cause suffering and decreased QOL #1 symptom that brings individuals to...

NCLEX PREP 2024 LATEST ACTUAL EXAM QUESTIONS WITH COMPLETE SOLUTIONS ANSWERED 100% GUARANTEED PASS What is the therapeutic index? ratio of toxic dose to therapeutic dose (LD50/ED50) Low therapeutic index means increased risk for drug toxicity Drugs with narrow therapeutic index digoxin, lithium, warfarin What is the heparin antidote protamine sulfate Warfarin antidote Vitamin K Local anaesthetics drug class -caine Lidocaine Therapeutic class: Local anesthetic Indication: Pa...

NR 293 Edapt Analgesic DrugsAnalgesic drugs are medications that relieve ______, but do not cause loss of consciousness. - correct answer Pain Opioids can be classified as mild agonists and strong agonists. __(1)___ agonists include codeine and hydrocodone, and ___(2)___ agonists include fentanyl, hydromorphone, meperidine, methadone, morphine and oxycodone. - correct answer Mild Strong 1. Sudden onset that subsides with treatment. 2. Skeletal muscle, ligament and joint pain. 3. Level o...

Match the route of a drug administration to its indication: Rectal - Used if patient is unable to take oral route. Match the route of a drug administration to its indication: intramuscular - Used for drugs when high blood levels or rapid effects are needed. Match the route of a drug administration to its indication: intrathecal - For local effects within the spine Match the route of a drug administration to its indication: Inhalation - For local effects within the respiratory Match the r...