Gms 6552 - Study guides, Class notes & Summaries

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GMS 6552 Exam 1
  • GMS 6552 Exam 1

  • Exam (elaborations) • 11 pages • 2024
  • Agonist Activation of GPCR - answer-Ligand binds Promotes conformational changes Increase in R Inverse Agonist Inhibition of GPCR - answer-Ligand binds Stabilizes inactive receptor conformations Antagonist Inhibition of GPCR - answer-Do not effect basal constitutive signaling Do not affect receptor conformation when they bind GPCR Full Agonist - answer-Produces full biological response GPCR Partial Agonist - answer-Can only produce partial biological response even at saturating c...
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GMS 6552
  • GMS 6552

  • Exam (elaborations) • 14 pages • 2024
  • Most common drug target - answer-- receptors Channel-linked receptors - answer-- ion channels open when bound to ligand - hyperpolarization or depolarization - milliseconds - ex. nicotinic receptor, ACh receptor G-protein coupled receptors - answer-- use second messenger systems to induce cellular effects when bound - seconds - ex. muscarinic ACh receptor Kinase-linked receptors - answer-- cause protein phosphorylation inducing cellular effects when bound -minutes - ex. insulin r...
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