Dna gyrase antimicrobials - Study guides, Class notes & Summaries
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Pre Test Pathophys micro exam I Already A+
- Exam (elaborations) • 19 pages • 2022
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1. A 28-year-old female with folliculitis is not responsive to a 10-day treatment course with penicillin. An enzyme produced by the etiologic agent is most likely responsible for this treatment failure. At which site on the molecule shown does this enzyme act to destroy penicillin? 
The structural integrity of the β-lactam ring in penicillins is essential for their 
antimicrobial activity. Many resistant strains of staphylococci produce a β-lactamase (penicillinase) that cleaves the β-lactam ...
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Antimicrobials Part 3: Miscellaneous Antibacterial Drugs
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Antimicrobials Part 3: Miscellaneous Antibacterial Drugs 
Fluoroquinolones “oxacins”: Broad-spectrum agents with multiple applications; Disrupt DNA replication 
and cell division; PO or IV; Resistance develops slowly but has become common in Neisseria 
gonorrhoeae 
Side Effects: generally mild but can cause tendon rupture (low risk)Usually affects Achilles 
tendon 
Contraindications: Avoid in patients younger than 18 years; Avoid in patients with myasthenia 
gravis; Risk to all patien...
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Antimicrobials Part 3 Miscellaneous Antibacterial Drugs
- Summary • 5 pages • 2023
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MICRO BIOLO 
Antimicrobials Part 3 
Miscellaneous Antibacterial Drugs 
Fluoroquinolones “oxacins”: Broad-spectrum agents with multiple applications; Disrupt DNA replication and cell division; PO or IV; Resistance develops slowly but has become common in Neisseria gonorrhoeae 
Side Effects: generally mild but can cause tendon rupture (low risk)Usually affects Achilles tendon 
Contraindications: Avoid in patients younger than 18 years; Avoid in patients with myasthenia gravis; Risk to all p...
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