Binding specificity - Study guides, Class notes & Summaries

Lipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equilibrium concentrations of dissolved substance in a two-phase system containing two largely immiscible solvents (water & octanol) - Log10(P) Improved Lipinski Parameters - ANSWER-1. Partition...

MCIM 321 Actual Questions and CORRECT Answers Allelic Exclusion - CORRECT ANSWER- Process by which only one allele of a gene is expressed and the other silenced Idiotype - CORRECT ANSWER- is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. Allotype - CORRECT ANSWER- the allele of the antibody chains found in the individual

T-cell receptors, when coexpressed with CDS mole cules, are restricted to recognizing and binding peptide fragments associated with A. CD3 molecules. B. CD4 molecules. C. MHC class I molecules. D. MHC class II molecules. E. MHC class Ill molecules. - The correct answer is C. cos+ T cells are re stricted to the recognition of pMHC I complexes. C03 molecules are associated with the TCR on the T-cell surface and are found on both mature C04+ and cos+ T cells. C04+ T cells are restricted to ...

PHR 4000 Exam 1a Question with complete solution 2023drug molecules that interact with specific targets/receptors of an organism to cause biochemical and physiological changes in an organism safety/efficacy What is largely the reason most new drugs fail? 1922, 14, animals insulin was first discovered to treat diabetes in ____ when a ___ year old boy was dying in the hospital. He was given insulin and within 24 hours he got better. First discovered the pancreas was involved throu...

MLT Clinical Chemistry Final Exam Latest Version Graded A Absolute binding Enzymes that can bind only one substrate and catalyze one reaction exhibit which type of binding specificity? Double The rate of an enzymatic reaction will ___________________ for every 10 degrees C temperature increase until the enzyme denatures. c. Myocardial infarction All of the following conditions may result in a rise in CKBB levels except. a. Child birth b Spinal chord injury c. Myocardial infarction d. Brain ...

MCMP 442 Exam 2 Questions and Answers 100% Pass Which is the most likely reason that HIV-infected people with heterozygous HLA loci have a delayed progression to AIDS compared with patients who are homozygous at one or more HLA loci? A. The greater number of HLA alleles provides a wider variety of HLA molecules for presenting HIV-derived peptides to CD8 T cells even if HIV mutates during the course of infection. B. Heterozygotes have more opportunity for interallelic conversion and can t...

MCMP 442 Exam 2 Questions and Answers 100% Pass Which is the most likely reason that HIV-infected people with heterozygous HLA loci have a delayed progression to AIDS compared with patients who are homozygous at one or more HLA loci? A. The greater number of HLA alleles provides a wider variety of HLA molecules for presenting HIV-derived peptides to CD8 T cells even if HIV mutates during the course of infection. B. Heterozygotes have more opportunity for interallelic conversion and can t...

MLT Clinical Chemistry Final Exam Questions and Answers | Latest Version | 2024/2025 | Already Passed **Q: What type of binding specificity is exhibited by enzymes that can bind only one substrate and catalyze one reaction?** - Enzyme binding - Absolute binding - Specific binding - Single binding **Absolute binding** **Q: What happens to the rate of an enzymatic reaction with every 10 degrees Celsius temperature increase until the enzyme denatures?** - Quadruples - Decreases ...

Absolute binding - Answer Enzymes that can bind only one substrate and catalyze one reaction exhibit which type of binding specificity? Double - Answer The rate of an enzymatic reaction will ___________________ for every 10 degrees C temperature increase until the enzyme denatures. c. Myocardial infarction - Answer All of the following conditions may result in a rise in CKBB levels except. a. Child birth b Spinal chord injury c. Myocardial infarction d. Brain tumor AST & ALT -...

What does controlled and selective expression of genes allow? - - development of multi-cellular organisms protein homologous found in the same organisms which have different functions are the result of... - gene duplication events In the A, B, C class of protein transport pump. The conformation changes that lead to translocation of the transporter substance are caused by... - - repeated cycles of ATP binding and hydrolysis in cells the strongest chemical interaction is? - - covalent bonds ...