Orthopaedic and Trauma Medicine PHARMACOLOGY II Y

Selective Cox-2 Inhibitors, Non Selective Cox- 2 Inhibitors, Paracetamol and other Non SelectiveCox-2Inhibitors Selective Cox-2 inhibitors • Are used in inflammatory disorders • They block the pathological part of prostaglandins and therefore lack GIT effect • Have a lower incidence of causing peptic ulcer, low incidence of platelet inhibition but lack cardioprotective effects • They have a high incidence of thrombotic effects • Not recommended in renal dysfunction Rofecoxib Is...