NURSING 2PF3 Module 1: Stress and Adaptation 3 o T-Helper 2 Shift: Depresses the activity of the T-helper 1 cells (thereby decreasing cell-mediated immunity) and promotes the activity of T-helper 2 cells (increasing humoral immunity)  Cardiovascular: o Enhances the effects of the catecholamines (Epi and NE) - Excessive cortisol (or excessive corticosteroid administration):  Cushing Disease  Excessive production of ACTH by the pituitary leading to excessive cortisol  Cushing sy...