Resume
Samenvatting prof. Van wijngaerden (alle leerstof inhoudstabel)
Cursustekst (hoorcolleges slides) met inhoudstabel. Alle te kennen leerstof voor prof. Van Wijngaerden.
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3 août 2018
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1. Resume - Prof. wilmer (alle leerstof inhoudstabel)
2. Resume - Prof. vanderschueren (alle leerstof inhoudstabel)
3. Resume - Prof. van wijngaerden (alle leerstof inhoudstabel)
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I NH OU D
Pathofysiologie...........................................................................................................................................................................................................................................................10
Microbiële virulente..............................................................................................................................................................................................................................................10
Primair pathogene micro-organismen...............................................................................................................................................................................................................11
Potenteel pathogene micro-organismen..........................................................................................................................................................................................................11
Opportunistsch pathogene micro-organismen.................................................................................................................................................................................................11
Pathogenese..............................................................................................................................................................................................................................................................11
Afweermechanismen.............................................................................................................................................................................................................................................12
Huid- en mucosa-barrière..................................................................................................................................................................................................................................12
Humorale afweermechanismen........................................................................................................................................................................................................................12
Cellulaire afweermechanismen.........................................................................................................................................................................................................................13
Epidemiologie............................................................................................................................................................................................................................................................13
Defenites...............................................................................................................................................................................................................................................................14
Reservoir................................................................................................................................................................................................................................................................14
Transmissie/overdracht.........................................................................................................................................................................................................................................14
Diagnose.................................................................................................................................................................................................................................................................14
Microbiologische diagnostee....................................................................................................................................................................................................................................14
Defenites...................................................................................................................................................................................................................................................................15
Etologie.....................................................................................................................................................................................................................................................................15
In/buiten zieeenhuis..............................................................................................................................................................................................................................................15
Geeende of ongeeende ingangspoort...................................................................................................................................................................................................................16
Prognose....................................................................................................................................................................................................................................................................16
1
, Piro.........................................................................................................................................................................................................................................................................16
Andere....................................................................................................................................................................................................................................................................16
Mortaliteit..............................................................................................................................................................................................................................................................16
Pathogenese..............................................................................................................................................................................................................................................................16
Infammatoire respons...........................................................................................................................................................................................................................................16
Effect..................................................................................................................................................................................................................................................................17
Doel....................................................................................................................................................................................................................................................................17
Ant infammatoire respons...................................................................................................................................................................................................................................17
Prognose....................................................................................................................................................................................................................................................................19
PIRO........................................................................................................................................................................................................................................................................19
Andere....................................................................................................................................................................................................................................................................19
Behandeling...............................................................................................................................................................................................................................................................19
Ant-infecteus beleid.............................................................................................................................................................................................................................................19
Supporteve (intensieve) zorgen............................................................................................................................................................................................................................19
Ant-infammatoire modulate...............................................................................................................................................................................................................................19
Bijzondere gevallen van sepsis..................................................................................................................................................................................................................................19
Sepsis zonder sprecefeee orgaanloealisate.........................................................................................................................................................................................................19
Zieete van Lyme: lyme borreliose..............................................................................................................................................................................................................................20
Symptomen............................................................................................................................................................................................................................................................20
Vroeg geloeealiseerde infecte: dagen tot weeen.............................................................................................................................................................................................21
vroege gedissemineerde infecte: weeen tot maanden....................................................................................................................................................................................21
Stadium 3 (late) : maanden tot jaren.................................................................................................................................................................................................................21
Prevente................................................................................................................................................................................................................................................................21
2
, Diagnose.................................................................................................................................................................................................................................................................21
Behandeling...........................................................................................................................................................................................................................................................21
Oorzaeen van therapiefalen..............................................................................................................................................................................................................................21
Syflis..........................................................................................................................................................................................................................................................................22
Kliniee.....................................................................................................................................................................................................................................................................22
Primair stadium..................................................................................................................................................................................................................................................22
Secundair stadium:............................................................................................................................................................................................................................................22
Latent stadium...................................................................................................................................................................................................................................................22
Tertaire stadium................................................................................................................................................................................................................................................22
Diagnose.................................................................................................................................................................................................................................................................23
Behandeling...........................................................................................................................................................................................................................................................23
Kattenerabzieete........................................................................................................................................................................................................................................................23
Kliniee.....................................................................................................................................................................................................................................................................23
Atypisch..............................................................................................................................................................................................................................................................23
Diagnose.................................................................................................................................................................................................................................................................23
behandeling...........................................................................................................................................................................................................................................................24
Brucellose...................................................................................................................................................................................................................................................................24
Besmetngsbronnen..............................................................................................................................................................................................................................................24
Symptomen............................................................................................................................................................................................................................................................25
DIagnose................................................................................................................................................................................................................................................................25
Behandeling...........................................................................................................................................................................................................................................................25
Infecteuze endocardits.............................................................................................................................................................................................................................................25
Voorbechiete factoren...........................................................................................................................................................................................................................................25
3
, Oorzaeelijee organismen.......................................................................................................................................................................................................................................25
Vegetate................................................................................................................................................................................................................................................................26
Gevolgen............................................................................................................................................................................................................................................................26
Typische letsels..................................................................................................................................................................................................................................................26
Diagnose.................................................................................................................................................................................................................................................................26
Behandeling...........................................................................................................................................................................................................................................................27
Prevente................................................................................................................................................................................................................................................................27
Acute bacteriële meningits.......................................................................................................................................................................................................................................27
Risicofactoren........................................................................................................................................................................................................................................................27
Symptomen en teeens...........................................................................................................................................................................................................................................27
Verwieeelingen...................................................................................................................................................................................................................................................28
Diagnose.................................................................................................................................................................................................................................................................28
Behandeling..........................................................................................................................................................................................................................................................28
Prevente................................................................................................................................................................................................................................................................28
Vaccinate bij einderen.......................................................................................................................................................................................................................................28
Vaccinate bij reizigers/pelgrims Meeea............................................................................................................................................................................................................29
Malaria.......................................................................................................................................................................................................................................................................29
Epidemiologie........................................................................................................................................................................................................................................................29
Cyclus.................................................................................................................................................................................................................................................................29
Stabiel vs onstabiel............................................................................................................................................................................................................................................30
Immuniteit.............................................................................................................................................................................................................................................................30
Symptomen............................................................................................................................................................................................................................................................31
Verwieeelingen...................................................................................................................................................................................................................................................31
4
, Diagnose.................................................................................................................................................................................................................................................................31
Behandeling...........................................................................................................................................................................................................................................................32
Geneesmiddelen................................................................................................................................................................................................................................................32
pREVENTIE..............................................................................................................................................................................................................................................................33
pREVETIE LOKALE BEVOLKING...........................................................................................................................................................................................................................33
Prevente bij reizigers.........................................................................................................................................................................................................................................33
Toxoplasmose............................................................................................................................................................................................................................................................33
Symptomen............................................................................................................................................................................................................................................................34
Congenitale toxoplasmose.................................................................................................................................................................................................................................34
Verworven toxoplasmose..................................................................................................................................................................................................................................34
Orgaanloealisates..............................................................................................................................................................................................................................................34
Diagnose.................................................................................................................................................................................................................................................................34
Behandeling...........................................................................................................................................................................................................................................................34
Schistosomiase...........................................................................................................................................................................................................................................................34
Cyclus.....................................................................................................................................................................................................................................................................35
Pathogenese en symptomen: 3 syndromen..........................................................................................................................................................................................................35
dermatts (cercariae) .........................................................................................................................................................................................................................................35
Katayama-eoorts (volwassen worm) .................................................................................................................................................................................................................36
Chronische fbro-obstructeve seewellen (eieren) .............................................................................................................................................................................................36
Diagnose.................................................................................................................................................................................................................................................................36
Behandeling...........................................................................................................................................................................................................................................................36
Prevente................................................................................................................................................................................................................................................................36
ECHOCOCCOSE...........................................................................................................................................................................................................................................................36
5
, Pathogenese en symptomen.................................................................................................................................................................................................................................37
Diagnose.................................................................................................................................................................................................................................................................37
Behandeling...........................................................................................................................................................................................................................................................37
Strongyloidiasis..........................................................................................................................................................................................................................................................37
Pathogenese en symptomen.................................................................................................................................................................................................................................38
Hyperinfecte syndroom....................................................................................................................................................................................................................................38
dIAGNOSE...............................................................................................................................................................................................................................................................38
Behandeling...........................................................................................................................................................................................................................................................39
Filariase......................................................................................................................................................................................................................................................................39
Lymfatsche flariase..............................................................................................................................................................................................................................................39
pathogenese en Cyclus......................................................................................................................................................................................................................................39
Symptomen........................................................................................................................................................................................................................................................39
Diagnose.............................................................................................................................................................................................................................................................39
Behandeling.......................................................................................................................................................................................................................................................40
LOA LOA.................................................................................................................................................................................................................................................................40
Pathogenese en cyclus.......................................................................................................................................................................................................................................40
Symptomen........................................................................................................................................................................................................................................................40
Diagnose.............................................................................................................................................................................................................................................................40
Behandeling.......................................................................................................................................................................................................................................................40
Onchocerca volvulus..............................................................................................................................................................................................................................................40
Pathogenese en cyclus.......................................................................................................................................................................................................................................41
Klinische symptomen.........................................................................................................................................................................................................................................41
Diagnose.............................................................................................................................................................................................................................................................41
6
, Behandeling.......................................................................................................................................................................................................................................................41
Infuenzavirus: griep...................................................................................................................................................................................................................................................41
sYMPTOMEN EN VERWIKKELINGEN..................................................................................................................................................................................................................42
Diagnose.............................................................................................................................................................................................................................................................42
Behandeling.......................................................................................................................................................................................................................................................42
Prevente............................................................................................................................................................................................................................................................42
Pandemische infuenza..........................................................................................................................................................................................................................................42
Gevolgen............................................................................................................................................................................................................................................................42
Pandemisch fasen who......................................................................................................................................................................................................................................43
Surveillance........................................................................................................................................................................................................................................................43
Avian infuenza.......................................................................................................................................................................................................................................................43
Infuenza A/ H5N1..............................................................................................................................................................................................................................................43
Infenza A/H7N9.................................................................................................................................................................................................................................................43
Seizoensgriep.........................................................................................................................................................................................................................................................43
Transmissie........................................................................................................................................................................................................................................................43
Herpes........................................................................................................................................................................................................................................................................44
Epstein Barr virus...................................................................................................................................................................................................................................................44
Transmissie........................................................................................................................................................................................................................................................44
Symptomen........................................................................................................................................................................................................................................................44
Diagnose en behandelingen..............................................................................................................................................................................................................................44
Cytomegalovirus....................................................................................................................................................................................................................................................44
Symptomen........................................................................................................................................................................................................................................................45
Behandeling en prevente..................................................................................................................................................................................................................................45
7
, Herpes simplex.......................................................................................................................................................................................................................................................45
Symptomen en transmissie...............................................................................................................................................................................................................................45
dIAGNOSE EN bEHANDELING.............................................................................................................................................................................................................................46
Varicella zoster.......................................................................................................................................................................................................................................................46
Symptomen, verwieeelingen, diagnose en behandelingen...............................................................................................................................................................................46
Hantavirus..................................................................................................................................................................................................................................................................46
Puumulavirus (noord-west- europa) .................................................................................................................................................................................................................47
HIV en AIDS................................................................................................................................................................................................................................................................47
HIV1....................................................................................................................................................................................................................................................................47
Gevolgen HIV..........................................................................................................................................................................................................................................................48
Diagnose.................................................................................................................................................................................................................................................................48
Behandeling...........................................................................................................................................................................................................................................................48
Antretrovirale therapie.....................................................................................................................................................................................................................................48
Combinatetherapie (combinaton antretroviral therapy cart) ........................................................................................................................................................................49
Profylaxie...........................................................................................................................................................................................................................................................49
Van dodelije naar chronische zieete......................................................................................................................................................................................................................49
Sarcoïdose..................................................................................................................................................................................................................................................................49
Etologie.................................................................................................................................................................................................................................................................49
Pathogenese..........................................................................................................................................................................................................................................................49
Kliniee.....................................................................................................................................................................................................................................................................50
Diagnose.................................................................................................................................................................................................................................................................50
Behandeling...........................................................................................................................................................................................................................................................50
Tuberculose................................................................................................................................................................................................................................................................51
8