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Descriptive & Analytic Epidemiology
Descriptive & Analytic Epidemiology 
How we view the world….. 
• Pessimist: The glass is 
half empty. 
• Optimist: The glass is 
half full. 
• Epidemiologist: As 
compared to what? 
Descriptive epidemiology 
• Attempts to explain the reason for disease 
occurrence. 
• Examines the distribution of disease in 
populations 
• Knowledge of such distributions is essential to 
describe patterns of disease as well as to help 
identify risk factors 
• Examines the characteristics ...
- Class notes
- • 16 pages •
Descriptive & Analytic Epidemiology 
How we view the world….. 
• Pessimist: The glass is 
half empty. 
• Optimist: The glass is 
half full. 
• Epidemiologist: As 
compared to what? 
Descriptive epidemiology 
• Attempts to explain the reason for disease 
occurrence. 
• Examines the distribution of disease in 
populations 
• Knowledge of such distributions is essential to 
describe patterns of disease as well as to help 
identify risk factors 
• Examines the characteristics ...
DEGENERATIVE DISORDERS & ACCUMULATIONS
DEGENERATIVE DISORDERS 
& ACCUMULATIONS 
Intracellular accumulations 
 Manifestations of cellular metabolic 
derangement that accumulates substances 
within the cells. 
 May accumulate cellular components or 
abnormal substances or pigments e.g 
I. Normal endogenous substances: 
May be produced at normal rates. The 
metabolic rate of its removal is 
inadequate e.g fatty change. 
II. Normal or abnormal endogenous 
substances: accumulating because of 
genetic or acquired defects in i...
- Class notes
- • 13 pages •
DEGENERATIVE DISORDERS 
& ACCUMULATIONS 
Intracellular accumulations 
 Manifestations of cellular metabolic 
derangement that accumulates substances 
within the cells. 
 May accumulate cellular components or 
abnormal substances or pigments e.g 
I. Normal endogenous substances: 
May be produced at normal rates. The 
metabolic rate of its removal is 
inadequate e.g fatty change. 
II. Normal or abnormal endogenous 
substances: accumulating because of 
genetic or acquired defects in i...
Lipids
Lipids 
Objectives 
1. Definition and functions of lipids 
2. Classification of lipids 
3. Chemical properties of lipids 
Definition: 
o Lipids are organic compounds formed mainly from alcohol and fatty acids combined 
together by ester linkage 
o Very important biomolecules 
o Insoluble in water 
o Soluble in organic solvents and other lipids 
o Lipids include fats, butter, ghee, lard, tallow, terpenes, steroids. Also vegetable oils such 
as olive oil, corn oil, soybean oil, semsem oil, sun f...
- Class notes
- • 15 pages •
Lipids 
Objectives 
1. Definition and functions of lipids 
2. Classification of lipids 
3. Chemical properties of lipids 
Definition: 
o Lipids are organic compounds formed mainly from alcohol and fatty acids combined 
together by ester linkage 
o Very important biomolecules 
o Insoluble in water 
o Soluble in organic solvents and other lipids 
o Lipids include fats, butter, ghee, lard, tallow, terpenes, steroids. Also vegetable oils such 
as olive oil, corn oil, soybean oil, semsem oil, sun f...
Proteins
Proteins	 
• Proteins account for more than 50% of the dry 
mass of most cells 
• Most	varied	of	the	biomolecules	 
• Categorized	by	func on 
Protein function 
Storage 
Examples: Casein, the protein of milk, is the major source of amino acids for 
baby mammals. Plants have storage proteins in their
- Exam (elaborations)
- • 33 pages •
Proteins	 
• Proteins account for more than 50% of the dry 
mass of most cells 
• Most	varied	of	the	biomolecules	 
• Categorized	by	func on 
Protein function 
Storage 
Examples: Casein, the protein of milk, is the major source of amino acids for 
baby mammals. Plants have storage proteins in their
Campylobacter & Helicobacter
Campylobacter & 
 Helicobacter 
General Characteristics 
Common to Superfamily 
 Gram-negative 
 Helical (spiral or curved) morphology; Tend to be 
pleomorphic 
 Characteristics that facilitate penetration and 
colonization of mucosal environments (e.g., 
motile by polar flagella; corkscrew shape) 
 Microaerophilic atmospheric requirements 
 Become coccoid when exposed to oxygen or 
upon prolonged culture 
 Neither ferment nor oxidize carbohydrates 
History...
- Exam (elaborations)
- • 59 pages •
Campylobacter & 
 Helicobacter 
General Characteristics 
Common to Superfamily 
 Gram-negative 
 Helical (spiral or curved) morphology; Tend to be 
pleomorphic 
 Characteristics that facilitate penetration and 
colonization of mucosal environments (e.g., 
motile by polar flagella; corkscrew shape) 
 Microaerophilic atmospheric requirements 
 Become coccoid when exposed to oxygen or 
upon prolonged culture 
 Neither ferment nor oxidize carbohydrates 
History...
Carbohydrate/Glucose Metabolism
Carbohydrate/Glucose Metabolism 
 (Glycolysis) 
Glycolysis: An Overview 
 • Glycolysis, the major pathway for glucose 
oxidation, occurs in the cytosol of all cells. 
 • It is unique, in that it can function either 
aerobically or anaerobically, depending on the 
availability of oxygen and intact mitochondria. 
 • It allows tissues to survive in presence or absence 
of oxygen, e.g., skeletal muscle. 
 • Red blood cells (RBCs), which lack mitochondria, 
are completely reliant on gluc...
- Class notes
- • 43 pages •
Carbohydrate/Glucose Metabolism 
 (Glycolysis) 
Glycolysis: An Overview 
 • Glycolysis, the major pathway for glucose 
oxidation, occurs in the cytosol of all cells. 
 • It is unique, in that it can function either 
aerobically or anaerobically, depending on the 
availability of oxygen and intact mitochondria. 
 • It allows tissues to survive in presence or absence 
of oxygen, e.g., skeletal muscle. 
 • Red blood cells (RBCs), which lack mitochondria, 
are completely reliant on gluc...
Cardiovascular disease
Cardiovascular disease 
COMMON PRESENTING SYMPTOMS OF HEART DISEASE 
Chest pain 
 Chest pain or discomfort is a common presenting symptom of cardiovascular 
disease and must be differentiated from non-cardiac causes. The site of pain, 
its character, radiation and associated symptoms will often point to the cause 
 Dyspnoea 
 Left heart failure is the most common cardiac cause of exertional dyspnoea 
 and may also cause orthopnoea and paroxysmal nocturnal dyspnoea. 
Palpitations 
 Palpitati...
- Class notes
- • 27 pages •
Cardiovascular disease 
COMMON PRESENTING SYMPTOMS OF HEART DISEASE 
Chest pain 
 Chest pain or discomfort is a common presenting symptom of cardiovascular 
disease and must be differentiated from non-cardiac causes. The site of pain, 
its character, radiation and associated symptoms will often point to the cause 
 Dyspnoea 
 Left heart failure is the most common cardiac cause of exertional dyspnoea 
 and may also cause orthopnoea and paroxysmal nocturnal dyspnoea. 
Palpitations 
 Palpitati...
An Illustrated Guide For Cardiovascular System Examination
An Illustrated Guide For 
Cardiovascular System 
Examination 
Bedside Teaching for 2nd year medical Students 
Prepared by: 
Dr. Farid Ghalli 
Clinical Teacher (Hon) 
2016 
 
 
 
 
 
Cardiovascular System 
Examination 
 Inspection 
 • Shape of precordium 
 • Apex beat 
 • Pulsation in other 
areas 
 a. Pulmonary 
 b. Parasternal 
 c. Aortic 
 d. Neck 
 e. Epigastric 
 f. JVP 
 Palpation 
 i. Apex beat 
localization 
 ii. Pulsation in 
following areas 
 • Pulmonary 
 •...
- Class notes
- • 143 pages •
An Illustrated Guide For 
Cardiovascular System 
Examination 
Bedside Teaching for 2nd year medical Students 
Prepared by: 
Dr. Farid Ghalli 
Clinical Teacher (Hon) 
2016 
 
 
 
 
 
Cardiovascular System 
Examination 
 Inspection 
 • Shape of precordium 
 • Apex beat 
 • Pulsation in other 
areas 
 a. Pulmonary 
 b. Parasternal 
 c. Aortic 
 d. Neck 
 e. Epigastric 
 f. JVP 
 Palpation 
 i. Apex beat 
localization 
 ii. Pulsation in 
following areas 
 • Pulmonary 
 •...
Examination of the Cardiovascular System
Topic 1: Review of Anatomy and Physiology 
Objectives 
At the end of the lesson the learner will be able to: - 
1) Describe the structure of the organs of the cardiovascular system 
2) Describe the functions of the cardiovascular system 
3) Explained the functional organization of the cardiovascular system 
1.0 Introduction 
The Circulatory system is a continuous circuit comprising of the cardiovascular system (heart and blood 
vessels) and lymphatic system (lymph vessels, lymph no...
- Class notes
- • 55 pages •
Topic 1: Review of Anatomy and Physiology 
Objectives 
At the end of the lesson the learner will be able to: - 
1) Describe the structure of the organs of the cardiovascular system 
2) Describe the functions of the cardiovascular system 
3) Explained the functional organization of the cardiovascular system 
1.0 Introduction 
The Circulatory system is a continuous circuit comprising of the cardiovascular system (heart and blood 
vessels) and lymphatic system (lymph vessels, lymph no...
CARDIOVASCULAR SYSTEM PHYSIOLOGY
CARDIOVASCULAR 
SYSTEM PHYSIOLOGY 
 A.N Malik 
Functions of the cardiovascular system 
 • Carrying of respiratory gases and nutrients 
 • Heat distribution 
 • Immunity 
Components of CVS 
 • Heart 
 • Blood vessels 
 • Arteries 
 • Arterioles 
• Capillaries 
• Veins 
General circuitry of CVS 
Functional histology
- Class notes
- • 67 pages •
CARDIOVASCULAR 
SYSTEM PHYSIOLOGY 
 A.N Malik 
Functions of the cardiovascular system 
 • Carrying of respiratory gases and nutrients 
 • Heat distribution 
 • Immunity 
Components of CVS 
 • Heart 
 • Blood vessels 
 • Arteries 
 • Arterioles 
• Capillaries 
• Veins 
General circuitry of CVS 
Functional histology