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PC707 Module 3-GI Questions And Complete Answers

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PC707 Module 3-GI Questions And Complete Answers Sodium-based antacids should be avoided in patients with cardiovascular disease Magnesium-containing antacids may cause diarrhea, contraindicated in renal insufficiency, may decrease absorption of warfarin (Coumadin) Bismuth subsalicylate cont...

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  • October 13, 2024
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PC707 Module 3-GI Questions And Complete
Answers

Sodium-based antacids should be avoided in patients with cardiovascular disease




Magnesium-containing antacids may cause diarrhea, contraindicated in renal insufficiency, may

decrease absorption of warfarin (Coumadin)




Bismuth subsalicylate contraindicated during pregnancy, lactation, in children <12 y/o




H2RA Examples Cimetidine (Tagamet), famotidine (Pepcid, Zantac 360), nizatidine

(Axid)




H2RA Indications Gastric and duodenal ulcers




H2RA MOA Blocks H2 receptors to reduce the volume of gastric acid (onset of action

slower than antacids but faster than PPIs - moderate acid reduction)




H2RA Safety Concerns Cimetidine is a potent CYP inhibitor, many D2D interactions

(warfarin, theophylline, phenytoin, opioids)

,PC707 Module 3-GI Questions And Complete
Answers

Potential pneumonia




Ranitidine (original Zantac) pulled off market d/t carcinogens, new formulation is famotidine




PPI Examples Omeprazole (Prilosec), esomeprazole (Nexium), lansoprazole (Prevacid),

pantoprazole (Protonix)




PPI Indications Gastric and duodenal ulcers




Most effective at suppressing acid but the slowest onset of action compared to antacids and

H2RAs




PPI MOA Prodrug inhibition of the proton pumps that secrete gastric acid




PPI Safety Concerns Fractures


Pneumonia

Acid rebound

, PC707 Module 3-GI Questions And Complete
Answers
C. diff

Can reduce the absorption of drugs that rely on acid




Prostaglandin Analog Example Misoprostol (Cytotec)




Prostaglandin Analog Indication Prevention of GI ulcers related to long-term NSAID use




Prostaglandin Analog MOA Protects gastric mucosa by binding to prostaglandin

receptors. This inhibits gastric acid secretion and increases mucus production




Prostaglandin Analog Safety Concerns Causes uterine contractions, therefore Category X

(contraindicated) in pregnancy




**Off-label use for induction of labor**




Mucosal Protectant Example Sucralfate (Carafate)




Mucosal Protectant Indication Antiulcer

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