NUR 2063 Essentials of Pathophysiology Essentials of Pathophysiology – Exam 2 What are the functions of the kidneys? - Regulation of blood pressure; regulating blood osmolarity; removal of toxins; bloo d filtration; activate vitamin D What are the clinical manifestations of benign prostatic hypertrophy? - dribbling; difficulty initiating urine stream; hesitancy; urinary retention, decreased stream What substance controls the reabsorption of water from the collecting ducts? - ADH - Anti Diuretic Hormone What is type 2 diabetes characterized as? - peripheral tissue insulin resistance What are the clinical manifestations of Graves’ disease? - Exophthalmos (bulging eyes), goiter, enlarge thyroid, heat intolerance, anxiety - hyperthyroidism What processes occur during fasting? - glucogenesis; glycogenesis What type of tissue is accessed to promote energy production in type 1 diabetes? - adipose/ fat What are the clinical manifestations of hypothyroidism? - myxedema, fatigue, cold sensitivity, constipation, weight gain What are the clinical manifestations of hyperthyroidism? - Goiter, fatigue, weight loss, infertility, memory loss, hair loss, muscle pain What are the clinical manifestation of hyper para thyroidism? - fatigue, body aches, bone pain, depression, headaches, memory loss What are the clinical manifestations of hypo para thyroidism? - numbness, tetany, parathesis, muscle spasms What are the clinical m anifestations of ketoacidosis? - fruity breath, drowsiness, nausea, thirst, confusion, lethargy, vomiting What mechanisms control hormone release and regulation? - negative feedback loop What hormones are released by the anterior pituitary gland? - Growth Hormone, prolactin, follicle stimulating hormone, thyroid stimulating hormone, LH, ACTH and endorphins What is diabetes insipidus? - a disorder caused by inadequate amounts of ADH which cause s excessive water loss clinical manifestations of diabetes insipidus - polyuria, nocturia, continuous thirst, and polydipsia clinical manifestations of Cushings syndrome? - Excessive secretion of cortisol causes redistribution of fat, "moon face", "buffalo" hump on the back and pendulous abdomen. - Facial skin is flushed (high blood pressure), skin covering abdomen develops stretch marks - •ndividual bruises easily and wound healing is poor - Approximately 1/2 develop mental status changes from irritability to severe psychiatric disturbance - Females may experience changes due to increased androgen levels clinical manifestations of secondary hypothyroidism - Weakness. - Fatigue. - Cold intolerance . - Constipation . - Weight gain. - Depression. - Joint or muscle pain. - Brittle fingernails.