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Chamberlain College of Nursing : NR565 Week 6 Study Guide / NR 565 Week 6 Study Guide: Advanced Pharmacology Fundamentals (LATEST, 2020) $12.49
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2020
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NR 565 (NR565)
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NR565 Week 6 Study Guide
CHAPTER 24: Drugs used in treating infectious disease
ANTIMYCOBACTERIALS
Mycobacteria- among the most difficult to cure (e.g. tuberculosis [TB])
o They grow slowly and are relatively resistant to drugs that are largely dependent on how
rapidly cells are dividing
o Have a lipid-rich cell wall relatively impermeable to many drugs
o Are usually intracellular and inaccessible to drugs that does not have good
intracellular penetration
o Have the ability to go into a dormant state
o Easily develop resistance to any single drugs
o Pregnancy categories:
Isoniazid: Pregnancy category A
Streptomycin: Pregnancy category D
The rest: Pregnancy category C
Fetal death- d/t TB: isoniazid + rifampin + ethambutol for TB tx if
pregnant and if drug resistance is a possibility.
Spectrum of coverage for various organisms/Pharmacodynamics
o Isoniazid - most active drug for tx of TB
Bactericidal- against susceptible mycobacteria (intracellular and
extracellular organisms)
Interferes with lipid and nucleic acid biosynthesis in growing organisms.
Isoniazid and ethambutol- inhibits synthesis of mycolic acid (important
constituents for mycobacteria cell walls and are not found in mammalian
cells).
o Rifamycins – rifampicin, rifabutin, rifapentine
Bactericidal- against susceptible mycobacteria
Bind to the beta subunit of mycobacteria DNA-dependent RNA
polymerase and inhibit RNA synthesis -> destruction of both multiplying
and inactive bacilli.
Readily penetrate most tissues and can kill bacteria that are poorly
accessible to many drugs.
Rifampin and rifabutin: N. gonorrhoeae, staphylococci, streptococci,
Mycobacterium leprae, MAC, and H. influenzae type B.
Rifampin-resistance develop rapidly when used as monotherapy- should
be combined with another active abx for tx of established infections.
o Ethambutol
Bacteriostatic- against susceptible mycobacteria (M. tuberculosis, M.
avium, M. kansasii)
Inhibits synthesis of arabinogalactan (an essential component of
mycobacteria cells walls).
Arrests cell multiplication -> cell death
, Enhances the activity of lipophilic drugs (rifampin and ofloxacin) that
cross the mycobacteria cell wall primarily in lipid portions of this cell
wall.
o Pyrazinamide- an analogue of nicotinamide
Bactericidal – against M. tuberculosis in an acidic environment (pH <5.6).
Useful in tx of TB
Exhibits good activity within macrophages and plays a key role in killing
intracellular organisms.
Shortening therapy and preventing relapses
Exact action is UNKNOWN.
o Streptomycin – aminoglycoside, used now almost exclusively to treat M.
tuberculosis infections.
Bactericidal in alkaline extracellular environment
Added as the 4th drug to the regimen for TB
Sensitive to M. avium and M. kansasii; resistant to all mycobacterium
Irreversible inhibitor of protein synthesis.
Penetrates cells poorly
o Ethionamide- similar binding site and mechanism of action as isoniazid.
Ultimately blocks the synthesis of mycolic acids.
Bacteriostatic – M. tuberculosis
Can inhibit some other Mycobacterium species.
o Capreomycin – peptide abx
Bactericidal to susceptible mycobacteria.
Inhibits RNA synthesis -> decreasing replication of M. tuberculosis.
Resistance easily develops when given as monotherapy (should be given
as part of multidrug regimen)
o Bedaquiline – unique antimycobacterial, approved by FDA in 2012
For tx of multidrug resistant TB
Inhibits mycobacterial adenosine triphosphate (ATP) synthesis
Active against replicating and dormant mycobacteria
Black-box warning: increased mortality as compared with a placebo tx
group.
Only to be used when an effective tx regimen cannot otherwise be
provided.
o Para-aminosalicylic acid- structurally similar to PABA and sulfonamides
Folate synthesis antagonist
Active almost exclusive against M. tuberculosis.
Bacteriostatic
Not used frequently – primary resistance is common, and other drugs are
better tolerated and less expensive.
Pharmacokinetics
o Oral antimycobacterials are rapidly and well absorbed in GI tract after PO
administration.
o Isoniazid- 90% bioavailable but should be taken on an empty stomach
, Readily diffuses into all body fluids including CSF (90% of serum levels),
pleural, and ascitic fluids
Readily diffuses into tissues, organs, saliva, sputum, and feces
Crosses placenta and breastmilk
Metabolism is extensive and highly variable and dependent on acetylator
status.
Primarily acetylated by the liver
50% of both blacks and whites are slow acetylators
Alaskan and Asians- majority are rapid acetylators
Rate of acetylator does not affect effectiveness but may increase
risk for toxic reactions with slow acetylators.
Excreted in the urine- metabolites, and unchanged drug
Elimination is largely dependent on renal function
o Rifamycins and ethambutol penetrate and concentrate in most body fluids.
Adequate CSF penetration occurs only in the presence of inflamed
meninges.
Potent inducers of liver metabolism
Rifampin and rifapentine- metabolized in the liver by deacetylation.
Metabolites are active against M. tuberculosis.
t1/2 life decreases with repeated administration
excreted primarily in the bile -> enterohepatic recirculation -> feces, urine
(small amount)
hepatic insufficiency and age slightly affect metabolism of rifabutin only.
Renal insufficiency- reduced drug distribution and faster drug elimination
-> decreased drug concentrations.
Food slow the rate of absorption of rifamycins but not the extent of
absorption (may be taken with or without food)
o Pyrazinamide- widely distributed in body tissues and fluids including the liver
and lung.
Reaches high concentrations in CSF
Crosses the placenta and enter breastmilk in small amounts
Poor CSF penetration (good penetration if meninges are inflamed)
70% excreted in urine by glomerular filtration
Hydrolyzed by the liver to as a metabolite
Prolonged t1/2 - significant on impaired hepatic and renal functions.
o Ethionomide- widely distributed to body tissues and fluids- CSF and serum
concentrations are equal
35% metabolized by the liver
Majority of the drug excreted in the urine as inactive metabolites
o Ethambutol- mainly excreted as unchanged drug in the urine.
20% metabolized by the liver
Marked accumulation may occur in renal failure
Pharmacotherapeutics
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