NR565
Final
Exam
Study
Guide
Drug Adverse Spectrum
Pharmacodynamics pharmotherapeutics Clinical use interaction reaction coverage Dose and monitoring Education
Drug
name
PCN, Inhibit biosynthesis Absorb through GI tract URI, pna, STI, Oral Gi affects, type Gram pos and Amox 250-500 Watch
pcn g of bacterial cell wall – depends on PH, UTI, wounds. H. contraceptives, 1 allergy, cdiff, some gram BUN and
and – mucopeptide. Bind excrete through urine. pylori, PUD, lyme, food and acidic rash neg use, strep, Clinical, cultures, lytes.
pcn v, to PBPs and lysis the Allergy, prego B. acute otitis media drinks, enterococcus, pathogen, suspectible Allergic
amoxo cell wall. Active unstable in acid, prolong sinusitis, bites diuretics, staph cdif reaction.
cillin cellular half life warafin, beat Complete
beta multiplication. blocker full course,
lactam empty
ase stomach
Cepha Good for rapidly Gi tract, kidneys Otitis media, Warafin, Serum sickness 1: gram pos – Cefazolin 250-500, Take with
lospori growing organisms, Hypersensitivity, renal sinusitis, anticoag, reaction, staph and cefalexin 250-500 food or
n, beta bacterialcidal function impairement, bronchitis, UTI, antacid, h2 seizures? Renal epidermidis milk, don’t
lactam heparic impairment with pharyngitis, STI, blocker, iron impairment 2: ^ cefprozil BUN, creat, PT, RBC take same
ase Beta lactamases. ceftriaxone, prego b, PNA, tissue Coag 3: gram neg, time as
ancef, 1&2: pos careful with children infection, strep, impairment strep, antacids,
kefazo 3&4: neg pharyngitis, STD, gonorrhea, e infection
l, UTI, PNA coli, salmonella control
Keflex 4: cefepime
, both pos and
roceph neg.
in pseudomonas
Fluroq Used against UTI, Found in bodily fluids. Bronchitis, pna, CPY450, Diarrhea, alter Gram neg – Cipro 500-750, 2 hour
uinolo gram neg, Synthesis Kidney. BBW of UTI, STI, diarrhea CYP3A4, taste, SJS, salmonella, Levaquin 5—750 after meal,
nes, and repair of bacterial tendinitis or tendon warfarin, phototoxicity, shigella, week. water,
cipro, DNA. Inhibit DNA rupture, QTC prolong, antacids, CV problems, meningitis, e INR, EKG, Renal same time
levaflo for transcription and MG, prego C, watch antiarythmias, tendon coli, klebsiella function full course,
xocin replication – gram renal impairment, and dm drugs rupture. BBW avoid sun
, pos. CNS stimulation, don’t
give under 18 yrs.
Lincos Binds to 50S Not affected by food, MRSA, alternative Erythromycin, n/v, metallic Gram pos, Clinda 150-300 Sit or stand
amide ribosome and metabolized by liver. to PCN with kaolin-pectin, taste, strep, after dose,
s, suppress protein Use carefully with allergy, respiratory, neuromuscular diphtheria, PCA testing, renal and food, let
clinda, synthesis asthma renal and liver dental blocker bacteroid, liver fx provider
cleocin impairment prego b acnes, tetani know if
surgery -
stop
Macro Binds to p site or 50s Prolong qt, cardiac Empirical Cyp3a4, Gi problems, Gram pos – Azithromycin 500, Empty
lides, ribosome and inhibits arrhythmia, electrolytes, treatment for Com CYP450, Orap, liver strep, mssa erythromycin stomach,
azythr protein synthesis, hepatotoxicity, MG, acq PNA, STI, class 1a and 3 abnormalities, Gram neg – give with
omyci weak base – alkaline visual disturbance. Prego chancroid, antiarrthmias, SJ. Statin - influenza, Hearing loss, ekg, water,
n, media. b and c chlymidia, PUD, fluconazole, myopathy Neisseria, liver values same time
erythr bronchitis, resp promethazine. ricketessa, each day
omyci issues antacids chlamidia,
n mycobacterium
Sulfon Inhibitition of Absorbed through Gi Combination GPD6 Rashes, skin Gram pos and Sulfa – loading dose Give with
amide dihydrofolate track, serum level 5-15. therapy – uti, deficincy, renal reaction, neg – klebsillea, then 2-4g/d water and
s, synthesis to prevent Metabolise in liver – burn, MRSA impairment, photosensitivit salmonella, CBC, UA make sure
*sulfa folic acid synthesis, slow metabolizer risk folate. y, SJS, gonorrhea, good urine
prevent purine and for toxicity prego c, Salicylates, hypersnesitivity protozoa output,
nucleic acids. give <2 mo. , PCN warafin, photosensit
allergy ivity by
Trime Converts Distributed throughout Uti, uri, bronchitis, Ace inhibitors, Rash, skin Gram pos and 100 mg q d for 10 day
thopri dihydrofolate to the body, kidney Mrsa ^ phenytoin reaction, neg – e colia,
m, tetrahydrofolic acid – excretion, prego c, not hyperkalemia salmonella, CBC, renal, liver
prims synthesis to pruines <2 mo shigella,
ol and DNA pertuisses
WITH SULFA –
sequential blocking
Nitrof Alter bacterial Absorbd slowly, watch UTI ^ anticholinergics Peripheral Gram pos and 50-100 qid with meals Give with
uranto ribosomes, low creat <40, prego b, not neuropathy, neg – staph, food, w
in concentration in body <1 mo pulmonary strep CBC, pulm eval urine may
high in urine, reactions be brown,
synthesis of DNA watch
and energy pulmonary
Lipogl Vanc, inhibit cell IV preferred, excreted in CDI, staph Aminoglycocid Nephrotoxicity, Gram pos – first Watch bun and creat Use with
ycope wall synthesis binds BM. Systemic – be es, ace CDI, prolong line, MRSA, cholesterya
ptides to membrane and careful with renal inhibitor, loop qt, vre, Staph 100-500 q6 6-10 mine hours
