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MCB 450 LON-CAPA AND CLICKERS EXAM 4 2025
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MCB 450 LON-CAPA AND CLICKERS EXAM 4 2025
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MCB 450 LON-CAPA AND CLICKERSEXAM 4 2025
High levels of ATP and citrate:
A. Indicate remote gluconeogenesis.
B. Inhibit glycolysis.
C. Indicate a high energy-well fed state.
D. All of the above
E. None of the above - Precise Answer ✔✔D. All of the above
Which of the following would be associated with LOW pyruvate
dehydrogenase rate?
A. High Acetyl CoA
B. Low Acetyl CoA
C. High pyruvate
D. Low ATP
E. High NAD+ - Precise Answer ✔✔A. High Acetyl CoA
The hallmarks of acute alcoholism without food intake are acidosis and
hypoglycemia. These metabolic changes are due to the:
,A. Metabolism of ethanol, which prevents the production of sufficient
levels of blood glucose from glycogen stores.
B. Increase of consumption of alcohol leads to acute inflammation of the
liver, which leads to massive consumption of glucose-6-phosphate as an
energy source and hypoglycemia in the serum.
C. Lack of food uptake (glucose) and the cellular metabolism of alcohol
generates high concentration of NADPH, which is favorable for
ketoacids production.
D. Oxidation of alcohol in the liver produces large amounts of acetyl-
CoA that increases the ketone bodies production and reduces
gluconeogenesis.
E. Cellular metabolism of alcohol generates a high ratio of
NADH/NAD, which shuts down liver gluconeogenesis. The body
increases lipolysis and utilizes fat as an energy source that produces la -
Precise Answer ✔✔E. Cellular metabolism of alcohol generates a high
ratio of NADH/NAD, which shuts down liver gluconeogenesis. The
body increases lipolysis and utilizes fat as an energy source that
produces large amounts of ketone bodies and lactate.
Hormonal activation of cyclic AMP levels will:
A. Phosphorylate PFK2 on a tyrosine residue.
B. Activate the PKC phosphorylation of PFK2.
C. activate protein kinase A phosphorylation of Fructose bisphosphatase
2.
D. Lead to the activation of PFK.
,E. Increase the activation of gluconeogenesis. - Precise Answer ✔✔E.
Increase the activation of gluconeogenesis.
Which of the following vitamins are precursors to coenzymes that are
necessary for the formation of acetyl CoA from pyruvate?
A. Thiamine, riboflavin, and lipoic acid
B. Thiamine, riboflavin, niacin, and biotin
C. Thiamine, riboflavin, niacin, lipoic acid, and pantothenic acid
D. Thiamine, riboflavin, niacin, lipoic acid, pantothenic acid, and biotin
E. None of the above. - Precise Answer ✔✔C. Thiamine, riboflavin,
niacin, lipoic acid, and pantothenic acid
In addition to pyruvate dehydrogenase, what other enzyme(s) in the
citric acid cycle has a key thiamine pyrophosphate coenzyme?
A. α-ketoglutarate dehydrogenase
B. Citrate synthase
C. Malate dehydrogenase
D. Isocitrate dehydrogenase
E. Aconitase - Precise Answer ✔✔A. α-ketoglutarate dehydrogenase
True or false?
TPP takes the acetyl group from lipoamide. - Precise Answer ✔✔False
, True or false?
The aconitase reaction isomerizes Citrate to Isocitrate through an
enediolate intermediate. - Precise Answer ✔✔False
True or false?
The aconitase reaction isomerizes Citrate to Isocitrate through an alkene
intermediate. - Precise Answer ✔✔True
True or false?
A biotin-deficient diet may lead to an increase of cytosolic acetyl CoA. -
Precise Answer ✔✔True
True or false?
The brain uses fructose instead of glucose for ATP production during
long-term fasting. - Precise Answer ✔✔False
True or false?
The thiol group of CoA attacks amide bond of acetyllipoamide to create
the thioester bond of acetyl-CoA. - Precise Answer ✔✔False
True or false?
CoA directly attacks pyruvate leading to a loss of CO2. - Precise Answer
✔✔False
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