Dementia with Lewy Bodies - Answer --rigidity
-Hallucinations
-Doesn't respond to dopamine , this is a degenerative dementia
-fluctuating cognitive impairment
Subcortical Dementia - Answer --slowing of psychomotor abilities and reduced attention
- Parkinson's and
-vascular dementia, multi-infarct
Sirtuin 1 - Answer --Regulates gene expression of various metabolic pathways
-MEDIATES THE BENEFICIAL EFFECTS OF CALORIC RESTRTRICTION
-Regulates glucose metabolism
-Increase in OsteoBLASTS, decrease in Adipocyes
Dietary Resveratrol - Answer --Mimics caloric restriction in MICE
-Inhibits gene expression associated with cardiac skeletal muscle aging in mice
-Modulates insulin mediated glucose uptake in muscle
-Makes yeast live 70% longer
-Acts a a fungicide in plants
-does Not alter SIRT1 levels
B Cells in Age-related Immune System Decline - Answer --Antigen presenting cells and
may help T cell development
-Increased in the offspring of healthy centenarians but total number do NOT typically
decline with age
High Exposure to Infections and Innate Immune System - Answer --affects type 1 and
type 2 T HELPER cell cytokine response
-Affects Toll-like receptor (TLR) mediated innate immune responses, early antigen
presenting cells
-Deleterious affect on the INNATE immune system
Oteoporosis - Answer -- INFLAMMATION is linked with ineffective bone remodeling and
increased bone resorption
-E2, Estradiol deficiency
-Aging and estrogen deficiency two biggest risks
-Osteoporosis and immunosenescence accompanied by TNF, IL-1 and RANK-1
increased osteoCLASTIC inflammation
, -loss of ALVEOLAR bone and teeth b/c of osteoCLASTIC activity
DHEA Oral Administration Elderly Men - Answer --Increases number of MONOcytes
between 2-20 weeks post treatment, 2-20 weeks
-10-20% increase in serum IGF-1 as early as 4 weeks
-Supplementation decreases lipofuscin accumulation in the brain in animals
Transdermal Estrogen - Answer --Reduces CAD
-Vasodilator
-Improves cholesterol, in humans and only transdermal
Progesterone - Answer --IV admin. blunts inflammatory cytokinde in TBI
Testosterone Replacement - Answer --Has shown to improve mood and muscle mass
-No effect on COGNITIVE ability
Women Menopause Changes - Answer --Testosterone, DHT, 3 androstenedione, and
estrogen
-Irritability and Depression
Low DHEA, and estrogen/progesterone imbalance - Answer --Increase body fat
-Decreases lean body mass
What improves low bone marrow density - Answer --Testosterone
-Growth Hormone
Testosterone Replacement Therapy - Answer --Improves Depressive Symptoms
-Promotes Lean muscle mass
-Improves Cholesterol profile
-improves visual and working memory in men
• Has shown to improve mood and muscle mass in andropausal men but did not affect
cognitive ability
Growth Hormone Deficiency (GHD) and CV M&M - Answer ---Normalizes IGF-1 and
HDL and decreases total and LDL
-Increase vascular mortality, increase plaque, intima-media thickness
-Decrease LV mm and ejection fraction
-Enhances production of Interferon-Gamma-Secreting cells (IFN-gamma-SC)
Improved HTN control - Answer --slashed stroke rate by 60%
-Ischemic heart disease by 53%
What % affected by HTN - Answer --more than 50% over age 65 in the form of Isolated
Systolic HTN
90% of HTN cases - Answer --Primary Essential HTN
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