Endotoxin and Septic Shock Exam Questions with Verified Answers (Rated 100%)
distributive shock - Answers vasodilation and loss of plasma volume owing to incrased vascular
permeability
septic shock - Answers G- spread to bloodstream, characterized by vascular collapse (decreased BP), DIC,
metabolic disturbance, MODS
monos, macros - Answers involved in septic shock
LPS (G-), TNFa - Answers causes septic shock
anaphylactic shock - Answers caused by allergens in the blood that activate mast cells > increased
vascular permeability, constriction of smooth m.; fluid leaving the blood causes BP to drop
allergen, mast cells - Answers involved in anaphylactic shock
S. aureus exotoxin, T cells - Answers involved in TSS
sepsis - Answers bacterial infxn w/ spread to blood
cytokines - Answers stimulate massive immune response in sepsis/septic shock
fever, increased HR/RR, PMNs - Answers sx of sepsis/septic shock
G-, G+, fungi - Answers orgs capable of causing sepsis
G- - Answers orgs most likely to cause sepsis/septic shock
LPS - Answers activator of innate immune system, stimulating leukos to release an array if cytokines and
chemokines that recruit inflammatory cells to the involved tissue as well as activating immune responses
O chain - Answers part of LPS that confers Ag specificity
O chain - Answers part of LPS that isn't conserved
core, lipid A - Answers part of LPS that is very conserved
outer core - Answers part of LPS that contains common sugars
inner core - Answers part of LPS that contains unique sugars
lipid A - Answers part of LPS that is toxic
TNF - Answers central mediator of immune response to LPS; reproduces effects of LPS
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