Exam (elaborations)
VTE TREATMENT: DOACS EXAM 2024/2025
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VTE TREATMENT: DOACS EXAM 2024/2025
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VTE TREATMENT: DOACS EXAM 2024/2025Dabigatran (Pradaxa) pros - Precise Answer ✔✔Reversible
Preferred agent on Kaiser formulary
Dabigatran (Pradaxa) cons - Precise Answer ✔✔Higher risk of GI
bleeding in patients >75
PGP DDIs
Requires 5 days of parenteral therapy
Dabigatran (Pradaxa) dose - Precise Answer ✔✔150 mg BID
Requires 5 days of parenteral therapy
Dabigatran (Pradaxa) contraindications - Precise Answer ✔✔CrCl < 30
mL/min
ESRD/HD
Dabigatran (Pradaxa) DDIs - Precise Answer ✔✔P-gp inducers or
inhibitors
Strong CYP3A4 inducers and inhibitors
, Dabigatran (Pradaxa) key points - Precise Answer ✔✔Reversible with
Idarucizumab
Apixaban pros - Precise Answer ✔✔Does not require parenteral therapy
first
Immediate anticoagulation - outpatient
Reversible and fewer DDIs
Can be given via G-tube or J-tube
Can be used with CrCl < 30 mL/min
Apixaban cons - Precise Answer ✔✔More expensive
Cannot monitor
Reversal agent is very expensive
Apixaban dose - Precise Answer ✔✔10 mg BID for 7 days
5 mg BID
Can dose reduce by 50% with strong CYP3A4 and P-gp inhibitors
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