TPMT And NUDT15 Testing In Acute Lymphoblastic Leu
TPMT and NUDT15 Testing in Acute Lymphoblastic Leu
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TPMT and NUDT15 Testing in Acute Lymphoblastic Leukemia Exam Questions and Correct Answers Latest Update (Rated 100%)
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TPMT and NUDT15 Testing in Acute Lymphoblastic Leu
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TPMT And NUDT15 Testing In Acute Lymphoblastic Leu
TPMT and NUDT15 Testing in Acute Lymphoblastic Leukemia Exam Questions and Correct Answers Latest Update (Rated 100%)
Acute Lymphoblastic Leukemia (ALL) - Answers Rare malignancy from immature lymphocyte overproduction.
6-Mercaptopurine (6-MP) - Answers Thiopurine drug used in ALL treatment phas...
Amino Acid Substitution - Answers Change in protein structure due to SNPs.
Ethnicity Prevalence - Answers SNP frequencies vary across different ethnic groups.
Leukemic Infiltration - Answers Lymphoblasts spread to other body areas.
, CNS Symptoms - Answers Headaches and blurred vision due to CNS involvement.
Hepatotoxicity - Answers Liver damage potentially caused by 6-MP metabolism.
TPMT*1 - Answers Normal function allele with standard enzyme activity.
TPMT*2 - Answers Common variant associated with reduced enzyme activity.
6-MP - Answers A thiopurine used in adult ALL treatment.
Apoptosis - Answers Programmed cell death induced by DNA damage.
Thiopurine S-methyltransferase (TPMT) - Answers Enzyme that metabolizes 6-MP to inactive form.
SNPs - Answers Genetic variations involving single DNA base changes.
TPMT Gene - Answers Gene located on chromosome 6p 22.33 encoding TPMT.
TPMT*3A - Answers Most common variant with two nucleotide transitions.
TPMT*3B - Answers Predominant variant in black patients, Ala154Thr mutation.
Methylation - Answers Addition of methyl groups affecting DNA function.
Bone Marrow Suppression - Answers Reduced blood cell production due to toxicity.
Genotyping - Answers Testing for specific genetic variants in patients.
Transporter Proteins - Answers Proteins facilitating drug transport across membranes.
Double Strand Breaks - Answers Severe DNA damage leading to cell death.
Active Metabolites - Answers Substances that exert therapeutic effects in treatment.
Cytotoxic Effects - Answers Cell damaging effects necessary for cancer treatment.
Inactivation Pathway - Answers Process leading to reduced activity of 6-MP.
c.719 A>G - Answers Mutation in TPMT gene leading to Tyr240Cys.
TPMT*3C - Answers Variant allele associated with reduced TPMT activity.
Codominant trait - Answers Both alleles contribute equally to phenotype.
Homozygous - Answers Having two identical alleles for a trait.
Heterozygous - Answers Having two different alleles for a trait.
Trimodal distribution - Answers Three distinct levels of enzyme activity observed.
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