Hematology- Acute lymphoblastic Leukemia Review Questions with Verified Solutions (Rated A+)
ALL is mostly a disease of ____________ and treatment has improved remarkably - Answers Children
In ALL, the malignant clone has an immunophenotype with features of an early lymphocyte or lymphoblast, typ...
ALL is mostly a disease of ____________ and treatment has improved remarkably - Answers Children
In ALL, the malignant clone has an immunophenotype with features of an early lymphocyte or
lymphoblast, typically expressing _________ and either B or T lymphocyte antigens - Answers TdT
What are the three FAB classifications of Acute Lymphoblastic Leukemias? - Answers L1 (SMALL
UNIFORM LYMPHOBLASTS)
L2 (LARGE, PLEOMORPHIC LYMPHOBLASTS)
L3 (Burkitt's Type)
This FAB class of Acute Lymphoblastic Leukemia is characterized by:
Exhibits a uniform population of small blasts with scant cytoplasm, a homogenous chromatin pattern
and inconspiciuous nucleoli - Answers L1 (small, uniform lymphoblasts)
This FAB class of Acute Lymphoblastic Leukemia is characterized by:
Nuclear shape is regular (occasional clefting may be present)
Patients have the best prognosis in this classification - Answers L1 (small, uniform lymphoblasts)
This FAB class of Acute Lymphoblastic Leukemia is characterized by:
Cellular heterogenety
May be difficult to distinguish from AML-M1 - Answers L2 (large pleomorphic lymphoblasts)
This FAB class of Acute Lymphoblastic Leukemia is characterized by:
Uniform population of relatively large blasts characterized by moderate to abundant, deeply basophilc,
vacuolated cytoplasm
Worst prognosis in this classification system - Answers L3 (Burkitt's type)
In the FAB classification system of ALL, L1 and L2 can be distinguished most reliably using the
____________ and presence or absence of nucleoli - Answers N:C ratio
The WHO classification system of ALL is based on _____________________ and whether the leukemic
population has the attributies of an early lymphocyte or lymphoblast - Answers Whether the clonal
lymphoblast population of B or T lymphocyte lineage
The following is characterized by:
The most frequently encountered form of lymphoblastic leukemia
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