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Exam (elaborations)

ACNP 1 DM- Questions and Answers

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ACNP 1 DM- Questions and Answers

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  • November 11, 2024
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  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • ACNP
  • ACNP
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ACNP 1 DM- Questions and Answers
First line treatment in DM type 2 Correct Ans-Metformin, no hypo and helps weight loss




Metformin contraindicated in Correct Ans-Renal failure, hold with radioactive dye




Second generation sulfonylureas Correct Ans-Glipizide, glyburide, glimepiride




Sulfonyleureas can causes Correct Ans-hypoglycemia, wt gain



the mechanism of action of sulfonylureas is as:

a. an antagonist of insulin receptor site activity

b. a product that enhances insulin release

c. a facilitator of renal glucose excretion

d. an agent that can reduce hepatic glucose production Correct Ans-b. a product that enhances
insulin release



hemoglobin A1c best provides information on glucose control over the past:

a. 1 - 29 days

b. 21 - 47 days

c. 48- 63 days

d. 64 to 90 days Correct Ans-d. 64 to 90 days

, Acarbose & Miglitol disadvantage Correct Ans-flatulance, not monotherapy




Piogitazone and Rosiglitazone Correct Ans-thiazolidinediones; Black box warning for HF,
measure ALT!



Meglintinides help with Correct Ans-post prandial Hyperglycemia




exenatide use can lead to Correct Ans-pancreatitis, gastroparesis, thyroid CA. GLP-1




mechanism of action of the DPP-4 Correct Ans-(gliptins) a drug that increases levels of
incretin, increasing synthesis and release of insulin from pancreatic beta cells



mechanism of action of exenatide Correct Ans-drug that stimulates insulin production in
response to increase in plasma glucose, slows gastric emptying



Somogyi Effect Correct Ans-Nocturnal hypoglycemia which rebounds to elevated glucose




Dawn phenomenon Correct Ans-tissue desensitized to insulin nocturnally. Progressively
elevated insulin throughout the night



DKA occurs in Correct Ans-Type 1 possibly from infection

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