100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
MN553 Pharmacology Unit 2 Quiz $8.49   Add to cart

Exam (elaborations)

MN553 Pharmacology Unit 2 Quiz

 4 views  0 purchase
  • Course
  • MN553 Pharmacology Unit 2
  • Institution
  • MN553 Pharmacology Unit 2

MN553 Pharmacology Unit 2 Quiz

Preview 1 out of 3  pages

  • November 7, 2024
  • 3
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • MN553 Pharmacology Unit 2
  • MN553 Pharmacology Unit 2
avatar-seller
Nursephil2023
MN553 Pharmacology Unit 2 Quiz
What properties affect the distribution of drugs - -drug size, charge,
chemical structure, pH, molecular size, lipid or water solubility

- first pass metabolism - -metabolism by the liver following oral
administration

- Phase 1 reactions - -Oxidation, reduction, hydrolysis or non-synthetic
reactions that prepare the drug for further metabolism - to make the drug
more water soluble

- Phase II reactions - -synthetic or conjugation reactions, something is
added to drug to make it more water soluble and more easily excreted by
the kidneys

- CYP P450 - -Liver *enzyme* that detoxifies substances,
Makes them easier to be excreted.

- single nucleotide polymorphism (SNP) - -minor mutations that can result in
metabolic activity changes, including increased and decreased drug
responses

- primary organ of excretion for drugs - -kidney

- blood flow differences in infants - -increased blood flow to muscles 1-6 mo
EXCEPT during illness, can cause slower or rapid perfusion

- Pediatric GI function - -pH increases gradually- reaches adult levels @ 20-
30 months preemies are even slower

- Diarrhea and kids - -kids with diarrhea have poor absorption of oral drugs

- Pediatric skin absorption - -Kids have thinner stratum corneum so topical
medications are absorbed more readily: increased risk of toxicity

- Infants and Lipid Soluble drugs - -decreased volume distribution, less
plasma proteins for binding, require higher doses of hydrophilic drugs

- CYP1A2 (phase 1 enzyme) pediatric - -reaches adult level by 4 mo and
then higher than adult levels through childhood then declines

- CYP2D2 (Phase 1 enzyme) pediatric - -absent or 5% active at birth reaches
adult levels by 3-5 yrs but has significant genetic variability

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller Nursephil2023. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $8.49. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

80364 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$8.49
  • (0)
  Add to cart