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Forgoros Anti-Arrythmic Drugs Questions and Correct Answers the Latest Update

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disopyramide therapeutic uses and electrophysiologic effects Class 1A uses: similar to quinidine (treat AFl, AF, reentrant SVTs, VT) use is limited by negative inotropic potential and strong anticholinergic propertiesterm-91 EP effects: blocks NA+ channel and slows depolarization, block...

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  • November 7, 2024
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  • Forgoros Anti-Arrythmic Drugs
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Forgoros Anti-Arrythmic Drugs
Questions and Correct Answers the
Latest Update
disopyramide therapeutic uses and electrophysiologic effects


✓ Class 1A
✓ uses: similar to quinidine (treat AFl, AF, reentrant SVTs, VT)
✓ use is limited by negative inotropic potential and strong anticholinergic
propertiesterm-91

✓ EP effects: blocks NA+ channel and slows depolarization, blocks K+ channel to
prolong refractory period

✓ comments: similar to quinidine (may suppress automaticity of purkinje fibers or
cause torsades de pointes) but causes fewer GI side effects
✓ dry mouth, eyes, and throat, urinary difficulty, urinary retention



Class 1a antiarrythmic drugs (the names of them)


✓ quinidine, procainamide, disopyramide



Class 1b antiarrythmic drugs (the names of them)


✓ lidocaine, mexiletine, phenytoin



Class 1 antiarrythmic drugs (explanation)


✓ have effect on the rapid sodium channel
✓ classified into 1a, 1b, 1c
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Class 1A antiarryhmic drugs effect on action potential


✓ slows upstroke of action potential (and thus slows conduction velocity)
✓ prolongs duration and refractoriness of action potential (because of blocking
potassium channel)



all drugs that prolong refractoriness can cause what


✓ early after depolarizations and thus torsades de pointes



quinidine effect on conduction velocity


✓ (like all class 1a)
✓ decrease ++



quinidine effect on refractory period


✓ (like all class 1a)
✓ increase ++



quinidine effect on automaticity


✓ (like all class 1a)
✓ suppress +



will quinidine cause afterdepolarizations?


✓ (like all class 1a)

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✓ may cause EADs



quinidine AF/AFl efficacy, AVN reentry efficacy macroreentry efficacy, PVCs,

VT/VF


✓ (like all class 1a)
✓ AF/AFl ++
✓ AVNRT +
✓ AVRT +
✓ PVCs ++
✓ VT/VF ++



major concern with all 1a drugs


✓ proarrhythmic
✓ early after depolarizations due to increased refractory periods that causes torsades
de pointes
✓ also any drug that alters conduction velocity can exacerbate reentrant arrythmias



any drug that alters conduction velocity can do what?


✓ exacerbate reentrant arrythmias



procainamide effect on conduction velocity


✓ (like all class 1a)
✓ decrease ++



procainamide effect on refractory period

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