Contains an acid, sodium thiosulfate, a buffer, and gelatin.
*Gelatin is used to maintain the particle size at 0.01 - 1 um
dpm = net cpm / efficiency
* NRC requires wipe testing must be recorded in dpm
*"efficiency" means efficiency of the well counter
SA node, AV node, Bundle of His, Purkinje fibers
a proton rich nucleus cannot meet the 1.02 MeV of energy required for a positron emission.
Definition 2 of 192
*F-18 Na Fluoride is the RP
*5 to 10 mCi is the dose range
*Injection time to Imaging time is 30 to 45 mins
*Very sensitive for bone metastatic disease for both osteoblastic and osteolytic cancers
Renal Imaging with Tc99m-DMSA (succimer)
Lung Quantitation
Bone Imaging with PET
P-32 Sodium Phosphate
,Term 3 of 192
A critical organ is?
Organ that receives the most radiation.
*used to decrease blood pressure, control heart rate, and reduce chest pain
Activity per volume (ex. mCi/mL)
greater flexibility for manipulation of data AFTER collection
Term 4 of 192
1 Ci=
37 GBq
radiolucent
Axumin
Prevents blood clots, is a blood thinner.
,Definition 5 of 192
*Tc99m-sestamibi is taken up into breast tumors as a result of the increased blood flow and
metabolic rate of neoplastic cells
*No spl pt prep is required, ask pertinent medical info about past mammograms, breast surgeries
*this should NOT be performed within 2 weeks of needle aspiration or within 4 to 6 weeks of
breast biopsy
*IV injection into arm contralateral to involved breast, if abnormalities are suspected in both
breasts, tracer should be injected into a vein in the foot
*Dose is 20 to 30 mCi
*Imaging begins 5 to 10 mins after injection
*Planar views of anterior chest and axillae, and lateral views of each breast, are acquired
**the lateral views are taken with the Pt in the PRONE position
*if nodule can be palpated additional images with a marker are taken
*Normal biodistribution salivary glands, thyroid glands, myocardium, liver, GB, intestines, skeletal
muscles, kidneys, and bladder
List mode allows?
Scintimammography
A critical organ is?
Lung Quantitation
, Definition 6 of 192
*is a mannosyl diethylene triamine penta-acetate (DTPA) dextran that targets the CD206 receptor
*molecule size is 7 nm
*binds to mannose receptors expressed by reticuloendothelial tissue including macrophages and
dendritic cells in lymph nodes which are present to T-cell lymphocytes
*advantage of this tracer is the rapid clearance from the injection depot and low accumulation in
second echelon nodes
*Dose is 0.5 mCi and used the same way filtered-SC is used for SLN imaging
*especially useful for head and neck melanoma
Ra-223 Dichloride (Xofigo)
First Pass Imaging Imp. Points:
P-32 Sodium Phosphate
Tc99m-Tilmanocept (Lymphoseek)
Definition 7 of 192
Deoxygenated blood enters the right atrium from the superior vena cavae. The right atrium and
ventricle are separated by the tricuspid valve. During ventricular diastole, (relaxation or filling
phase), the tricuspid valve opens, allowing blood to flow from the right atrium into the right
ventricle. The blood exits the right ventricle during ventricular systole, (contraction phase), and
travels through the pulmonary valve into the pulmonary artery, which leads into the lungs. Carbon
dioxide and oxygen are exchanged in alveoli of the lungs. Blood becomes oxygen rich, newly
oxygenated blood enters the left atrium by way of the pulmonary veins. Blood then passes
through mitral valve into LV during ventricular diastole. This blood is introduced into circulation
during ventricular systole by passing through aortic valve and into aorta.
Salivary Gland Imaging Imp. Points:
In-111 Capromab Pendetide (ProstaScint)
Path of blood through the heart and lungs to body.
SPL NOTE: About what happens to Te when the Tp and Tb are DRASTICALLY different
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