,1. Which of the following neurotransmitter systems is primarily
implicated in the pathophysiology of schizophrenia?
- A) Serotonin
- B) Dopamine
- C) Norepinephrine
- D) Acetylcholine
Correct Answer: B) Dopamine
Rationale: Schizophrenia is mainly associated with
dysregulation in the dopamine system, especially hyperactivity in
the mesolimbic pathway.
2. Which medication is classified as an atypical antipsychotic?
- A) Haloperidol
- B) Chlorpromazine
- C) Clozapine
- D) Fluphenazine
, Rationale: Clozapine is an atypical antipsychotic with lower
risk of extrapyramidal side effects and is effective in treatment-
resistant schizophrenia.
3. The ‘cheese reaction’ is associated with the use of which class of
antidepressants?
- A) SSRIs
- B) SNRIs
- C) MAOIs
- D) Tricyclics
Correct Answer: C) MAOIs
Rationale: MAOIs can cause hypertensive crises when foods
high in tyramine (like cheese) are consumed.
4. Which of the following drugs is considered a mood stabilizer?
- A) Fluoxetine
- B) Valproic acid
- C) Risperidone
- D) Diazepam
, Rationale: Valproic acid is used as a mood stabilizer in the
treatment of bipolar disorder.
5. Which psychotropic medication requires regular monitoring of
white blood cell counts due to the risk of agranulocytosis?
- A) Risperidone
- B) Quetiapine
- C) Clozapine
- D) Olanzapine
Correct Answer: C) Clozapine
Rationale: Clozapine can cause agranulocytosis, a potentially
life-threatening reduction in white blood cell count.
## Fill-in-the-Blank Questions
6. The most prominent theory explaining the mechanism of action
of Selective Serotonin Reuptake Inhibitors (SSRIs) involves the
blockage of serotonin _______________.
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