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QUESTIONS COMPLETE
WITH DETAILED VERIFIED
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ANSWERS 100% CORRECT
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,The 1/2 life of lithium is about?
24 hours
Fluoxetine is the SSRI with the ______ WD risk?
lowest due to long half life
What antipsychotics are good for pts who miss doses of their meds?
Antipsychotics with long half-lives:
K
1. Cariprazine(Vrylar): (2-4 days-active metabolites up to 3 weeks)
2. Abilify (3 days)
3. Brexpiprazole (4 days)
C
4. Pimozide (4-5 days)
5. Pimavanserin (2 days, active metabolites 8 days)
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Disulfiram's alcohol interactions persist for up to how long after the medication is stopped?
LONG Half life--2-3 days
persist up to 2 weeks following stopping
YC
What is the only TCA with a long half life?
Protriptyline (Vivactil)
D
Most psychotropics have a medium range 1/2 life of approx?
24 hours
U
what does "steady state" mean in relation to 1/2 life?
ST
steady state means that you are eliminating the drug at the same overall rate that you are
ingesting it
Lithium reaches its 'steady state' when?
5 half lives
example:
Day 1: Start pt on Lithium 600 mg daily
, Day 2: (24 hours later) the amount left in his body is 300 mg (day 2 min) because 24 hours has
passed--one 1/2 life--therefore the pt has excreted 1/2 of the initial amount.
THEN the pt takes his 2nd dose of 600 mg on DAY 2-resulting in a max dose of 900 (300 mg left
in body + 600 mg of 2nd dose).
DAY 3: starts off with 450 mg (1/2 of the 900 mg in pt's system) and after taking the day 3 600
mg dose, the pt now has a total of 1050 mg.
K
Due to the steady state of Lithium, when do we draw a blood level?
5 half lives
C
if you check any earlier, the trough level will underestimate the actual level the pt is on after
achieving steady state
LO
Fluoxetine has a half life of about?
2 weeks 1/2 life
YC
take 2.5 months to achieve steady state
Most psychotropic medications operate in this fashion:
"when you double the dose, the serum dose doubles."
D
*minus three SRIs and three anticonvulsants (Fluoxetine, fluvoxamine, paxil, gabapentin,
valproate and carbamazepine)
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_________induces it's own metabolism, hastening excretion and shortening it's half life
A. Carbamazepine (Tegretol)
ST
*this effect begins to "rev up" after 2-4 weeks--which is why a carbamazepine level is so
important on obtaining 1-2 months after starting Tegretol.
3 multiple choice options
Carbamazepine (Tegretol) level should be checked how soon after starting to take this med?
1-2 months due to Tegretol inducing it's own metabolism, hastening excretion and shortening it's
half life.
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