Molecular Biology Final - Exam 3 2024/2025 with 100% correct answers
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Course
Molecular Biology Fal - E3
Institution
Molecular Biology Fal - E3
What would be the effect of an antibiotic that bound to the ribosome in the manner of a Class I release factor but prevented RRF binding?
a. Prevent ribosome recycling, thus reducing overall protein synthesis
b. Cause translation run-through, so that most proteins contained many extra amino aci...
What would be the effect of an antibiotic that bound to the ribosome in the manner of a Class I release
factor but prevented RRF binding?
a. Prevent ribosome recycling, thus reducing overall protein synthesis
b. Cause translation run-through, so that most proteins contained many extra amino acids and were thus
non-functional
c. Inhibit chain elongation, so that most proteins are truncated and thus non-functional
d. Inhibit small subunit recognition of mRNA sequences, reducing overall protein synthesis correct
answersa. Prevent ribosome recycling, thus reducing overall protein synthesis
The required sequence elements needed for group I intron splicing are
a. short conserved sequences at the very ends of the intron
b. no conserved sequence elements or secondary structure
c. a characteristic secondary structure based on conserved internal inverted repeats
d. conserved sequence elements in the center of the intron correct answersc. a characteristic secondary
structure based on conserved internal inverted repeats
Bacterial trans-encoded sRNA is usually expressed
A. as a response to the presence of foreign nucleic acids
B. as a response to changes in the cellular environmental conditions
C. as a response to invading pathogens
D. consitutively correct answersB. as a response to changes in the cellular environmental conditions
If the host cell cap binding complex is inactivated in a poliovirus-infected cell, how would this influence
the translation of poliovirus mRNA?
,a.Polio viruses mRNAs have viral caps; polio viruses provide their own translation factors which
recognized polioviral caps on poliovirus mRNAs
b. Only some of the viral mRNAs would not be translated because polio virus produces a secondary cap
binding complex made up of distinct subunits that are not susceptible to inactivation.
c. Because polio viruses are dependent on host cells for protein synthesis, viral protein synthesis would
be inhibited, and no viruses would be produced by the cell.
d. There would be no effect because polio virus mRNAs are not capped, but instead contain internal
ribosome entry sites. correct answersd. There would be no effect because polio virus mRNAs are not
capped, but instead contain internal ribosome entry sites.
Ribonuclease P is involved in tRNA maturation as
a. a ribonucleoprotein with an RNA that is essential for catalysis and a protein component that maintains
RNA structure
b. an RNA molecule with both tRNA binding and cleavage activities
c. a protein with both tRNA binding and cleavage activities
d. a ribonucleoprotein with a protein component that is essential for catalysis and an RNA that is
important for maintaining structure correct answersa. ribonucleoprotein with an RNA that is essential for
catalysis and a protein component that maintains RNA structure
In the Arava etal 2003, what information was obtained from hybridization microarrays?
A. number of ribosomes bound to the mRNA
B. relative amounts of DNA in each sample
C. relative amounts of RNA present in a sample
D. relative amount of protein present in a sample correct answersC. relative amounts of RNA present in a
sample
The first step in translation initiation in bacteria is:
a. association of IF-1 and IF-3 with the 30S ribosomal subunit
, b. association of initiator tRNA with the 30S ribosomal subunit
c. association of mRNA with the 30S ribosomal subunit
d. 50S subunit binding to the 30S ribosomal subunit correct answersa. association of IF-1 and IF-3 with
the 30S ribosomal subunit
Termination of translation is characterized by _____.
a. entry of chaperonins into the E site to release polypeptide chain
b. binding of a special uncharged terminator tRNA to the terminator codon and release of polypeptide
chain
c. binding of EF-2 to the E site to release polypeptide chain
d. recognition of stop codon in A site by protein release factor and release of polypeptide chain correct
answersd. recognition of stop codon in A site by protein release factor and release of polypeptide chain
What is the basis of interaction between the ribosome and an mRNA in bacterial translation initiation?
a. Specific interaction between ribosomal proteins and a binding protein that associates with the SD in
the 5' end of the mRNA
b. Specific protein-RNA interactions occur between ribosomal proteins and the mRNA
c. Specific base pairing between the antiSD in the 3' end of the 16S rRNA in the 30S subunit and a
conserved SD sequence in the mRNA
d. Specific base paring between the antiSD in the 5' end of the 16S rRNA in the 30S subunit and a
conserved SD sequence in the mRNA correct answersc. Specific base pairing between the antiSD in the 3'
end of the 16S rRNA in the 30S subunit and a conserved SD sequence in the mRNA
In the presence of thyroid hormone, TR-RXR heterodimer activates transcription. What happens in the
ABSENCE of hormone?
a. TR-RXR is present in the nucleus but is sterically hindered from binding TRE
b. Heterodimer formation is prevented because RXR is sequestered in the cytoplasm
c. Heterodimer formation is prevented because TR is sequestered in the cytoplasm
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