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PCB 3233 - Immunology Exam 3 questions with correct answers
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PCB 3233 - Immunology Exam 3 questions with correct answers
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PCB 3233 - Immunology Exam 3 questions with correctanswers
Helper T cells associate with which class of MHC molecules? - ** VERIFIED ANSWERS **✔✔MHC
Class 2 (extracellular infection)
Interferon function - ** VERIFIED ANSWERS **✔✔Viral fighting, they activate NK cells which then
tell our infected cells to die by apoptosis.
What process creates the variable region domain for both TCRs and BCRs? - ** VERIFIED
ANSWERS **✔✔Somatic Recombination
What the different types IFN-1? - ** VERIFIED ANSWERS **✔✔Alpha and Beta
What are the differences and similarities between CD8 T Cells and NK cells? - ** VERIFIED
ANSWERS **✔✔The both have the same cytotoxic granules, NK cells are activated faster, because
they come out of the bone marrow "ready to go". CD8 T cells recognizes MHC Class 1 + peptide
(antigen) on a pathogen, while NK cells recognize normal MHC Class 1 molecules on the surface of
our cells and activating ligands that infected cells put up on their surface.
2 types of activating ligands - ** VERIFIED ANSWERS **✔✔MIC - A and MIC - B, they bind to
activating receptors on activating NK cells
Type 2 interferon - ** VERIFIED ANSWERS **✔✔Also know as IFN- gamma, activates
macrophages
IL - 12 - ** VERIFIED ANSWERS **✔✔Inflammatory cytokine that activates NK cells which then
produces IFN - gamma which then activate macrophages.
Which complement receptors can recognize C3b? - ** VERIFIED ANSWERS **✔✔CR 1 - CR 4
, Which Professional Antigen Presenting Cell (Professional - APC) is strong enough to activate a CD8
T cell from a naive state? - ** VERIFIED ANSWERS **✔✔Dendritic cells
C3 convertase of the Alternative Pathway - ** VERIFIED ANSWERS **✔✔C3bBb
When will NK cells make interferon gamma? - ** VERIFIED ANSWERS **✔✔When they are
activated by IL-12 (inflammatory cytokine)
Explain the activation of macrophage feedback loop - ** VERIFIED ANSWERS **✔✔NK cells
become activated by IL- 12, they produce interferon gamma, IFN- gamma activates macrophages,
macrophages secrete IL-12 (+ other cytokines)
Describe the chains in a TCR? - ** VERIFIED ANSWERS **✔✔V region followed by a C region
followed by a membrane anchoring domain
Where is the most variable region of the TCR? - ** VERIFIED ANSWERS **✔✔V-alpha and V- beta
CDR - ** VERIFIED ANSWERS **✔✔area of hypervariability condensed in loops in domain farthest
from the T cell membrane
How many CDRs does each TCR chain have? - ** VERIFIED ANSWERS **✔✔3, CDR 1 - 3
How many binding sites do TCRs have? - ** VERIFIED ANSWERS **✔✔1 binding site for antigen
What is the fundamental difference between T cells and B cells? - ** VERIFIED ANSWERS **✔✔T
cells do not undergo any further changes after antigen stimulation whereas B cells continue to
diversift
Function of B cells - ** VERIFIED ANSWERS **✔✔mediating effector functions
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