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PHMY 610 HEPATOVIRIDAE & RETROVIRUSES EXAM 2 QUESTIONS AND VERIFIED ANSWERS
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PHMY 610 HEPATOVIRIDAE & RETROVIRUSES EXAM 2 QUESTIONS AND VERIFIED ANSWERS....
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PHMY 610 HEPATOVIRIDAE & RETROVIRUSES EXAM 2QUESTIONS AND VERIFIED ANSWERS
this is a family of pathogenic viruses which preferentially invade the cells of the
liver resulting in hepatitis
hepatoviridae
acute viral hepatitis is a short-term infection usually lasting how long??
4-8 weeks
chronic viral hepatitis is a persistent infection lasting how long??
longer than 6 months
acute viral hepatitis infection can be asymptomatic but what are some non-
specific viral symptoms that may be seen?
malaise, fever, aches, N/V, abdominal pain, joint pain
acute viral hepatitis infection can be asymptomatic but what are some more
specific symptoms that may be seen?
jaundice, icterus, dark urine, clay-colored stool
is chronic viral hepatitis usually symptomatic or asymptomatic
asymptomatic
what family is the hepatitis A virus in
picornaviridae
hepatitis A virus includes a capsid surrounding what type of genome
positive ssRNA genome
T/F: the hepatitis A virus is strongly resistant to inactivation such as acids and
detergents
true
how many serotypes does the hepatitis A virus have
, only 1
hepatitis A virus is transmitted how?
contaminated food and water (also blood) [fecal-oral route]
how does hepatitis A virus enter the bloodstream
from epithelial lining of oropharynx or intestines
once hepatitis A virus travels to the liver, what does it attach to
parenchymal cells of the liver
where does hepatitis A virus replicate
hepatocytes and kupffer cells of the liver and then released into bile and stool
T/F: hepatitis A virus is cytolytic and is not shed via exocytosis
false, it is NOT cytolytic and is shed via exocytosis
hepatitis A virus has heavy viral shedding approximately ______ days before
symptoms appear
10 days
what are some components of innate immunity involved in hepatitis A virus
response
interferon, NK cells, cytotoxic T cells
what are some components of adaptive immunity involved in hepatitis A virus
response
antibody, complement (leads to icterus and increased ALT)
T/F: antibody protection vs hepatitis A virus is long term
true
how % of acute hepatitis is caused by hepatitis A virus
40%
what are some risk factors for hepatitis A virus transmission
overcrowded, unsanitary conditions, day-care centers, homeless population
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