PHAR 100 Final Exam From Jud Questions
And Answers Graded A+.
Codeine - correct answer. 0.5% opium
Pain relief
Morphine - correct answer. 10% opium
Immense pain reliever
Gold standard drug
Curare - correct answer. Indigenous people dipped arrows, causing paralysis to
animals
Paul Enrlich (father of chemo)
Gerhard Domagk
Alexander Fleming
Selman Waksman
Morton - correct answer. Organoarsenicals--> syphilis
Sulfa drugs
Penicillin
Streptomyocin (TB)
Ether
Receptor - correct answer. Molecule located on the inside or outside of a cell that
has a regulatory role in homeostasis
Agonists - correct answer. Drugs that bind to a receptor and stimulate it
Antagonists - correct answer. Drugs that bind to a receptor but block the response
that it normally elicits
Dose-Response Relationship - correct answer. Intensity is proportional to dosage
Low dose = little response; not enough receptors activated
Threshold dose = enough receptors activated to elicit response
, Past threshold = small increments in dose lead to increasing intensity in response
Max effect = maximal response; once you increase the dose past maximum there is no
increase in response
ED 50 - correct answer. Dose that results in 50% of the maximum effect
Dose that is effective in 50% of the population
Efficacy - correct answer. The maximum response that can be produced by a drug
Potency - correct answer. The strength of the drug
The amount that must be given in order to get a certain response
Therapeutic Range - correct answer. The dose of a drug that keeps blood
concentrations above the minimum needed for a response but below the toxic response
concentration
In between ineffective and toxic
Bioavailability - correct answer. The fraction of the administered drug that enters the
bloodstream (i.e. 100% for IV administration)
Absorption - correct answer. Movement of a drug from site of administration to the
blood
Distribution/Redistribution - correct answer. Movement of a drug from blood to the
site of action (i.e. tissue)
Metabolism/Biotransformation - correct answer. Conversion of a drug to a different
chemical compound; occurs mainly in the liver
Excretion - correct answer. Moving a drug and its metabolites out of the body
Half Life - correct answer. Time needed for the liver and kidney to remove half of the
drug from the body
Teratogenesis - correct answer. Drug produces birth defects
Therapeutic Index (TI) - correct answer. = TD50/ED50
Higher TI = Safer Drug
Lower TI = Greater chance of toxicity
TD 50 - correct answer. The dose that is toxic in 50% of the population
Drug-Drug Interactions - correct answer. One drug changes the pharmacological
effect of a second drug
- alters the absorption, metabolism or excretion of the other
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