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Pharm 124 EXAM Questions and Answers 100% Solved | Latest Update
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Pharm 124 EXAM Questions and Answers 100% Solved | Latest Update Define Pharmaceutics - -study of chemical, physical and biological factors of drug forms to determine the most effective and stable product The study of how various drug forms influence the way in which the drug affects the bod ...

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  • November 1, 2024
  • 40
  • 2024/2025
  • Exam (elaborations)
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©NINJANERD 2024/2025. YEAR PUBLISHED 2024.
Pharm 124 EXAM Questions and

Answers 100% Solved | Latest Update


Define Pharmaceutics - ✔✔-study of chemical, physical and biological

factors of drug forms to determine the most effective and stable product

The study of how various drug forms influence the way in which the drug

affects the bod

what is a drug - ✔✔an agent used for the diagnosis, treatment, reduction,

prevention, or curing of an illness

dosage form vs drug delivery system - ✔✔dosage form: preparation and

way drug is presented to person

dosage form can be drug delivery system: it is microscopic carrier eg

nanoparticle that encapsulates and targets drug to specific location

general dosage forms and examples - ✔✔1) solids: capsules, tablets,

powder

2)liquid: solutions and some dispersions

3) semi-solid: cream, ointment, gel, suppository

,©NINJANERD 2024/2025. YEAR PUBLISHED 2024.
what is a drug product? generic vs brand name - ✔✔formulation of a drug

specifying the drug itself, excipients, dosage form, and method of

preparation

Brand name/ Innovator:

rationale for different dosage forms and factors that influence the form

chosen - ✔✔Rationale:

-same and convenient means to deliver an accurate dose

-protect the drug from degradation from either GI tract or environment

-hide any unpleasant tastes

-ensure or control the release of the drug into the body and to achieve a

predictable therapeutic response



Factors/considerations:

biopharmaceutic considerations: factors affecting bioavailability- factors

affecting absorption of drug from different routes of administration Drug

factors: physical and chemical properties of the drug itself

Therapeutic considerations: disease and patient factors

What are drug factors in terms of dosage form - ✔✔physical and chemical

properties of the drug itself. Includes:

-structural properites

,©NINJANERD 2024/2025. YEAR PUBLISHED 2024.
-polymorphism

-dissolution

-particle size, solubility, partitioning

-stability

-organoleptic properties

-mechanism of decomposition

-interactions with other excipients

what are the therapeutic considerations in dosage form design -

✔✔Therapeutic: nature of illness, disease, indication determines whether

we need:

-systemic or local delivery

-targeted delivery

-required duration of action

-dose (amount given)

-dose regimen: drug, dose amount, interval between doses, duration of

therapy

-fast or sustained or controlled release

-patient characteristics

-age, emergency conditions

, ©NINJANERD 2024/2025. YEAR PUBLISHED 2024.
what are the biopharmaceutic considerations of dosage form design -

✔✔ADME priniciple:

Absorption, Distribution, metabolism, elimination

-forms that avoid first-pass metabolism require less dose and has faster

onset

types of effects a drug can have and what are the administration routes?

what affects this - ✔✔local vs systemic

Local: topical, transdermal, otic, opthalamic, conjunctival, nasal, inhalation

etc

Systemic:

-enteral: oral, sublingual, buccal, rectal (can also be local)

-parenteral: intravenous, intramuscular, subcutaneous, intraosseous etc



What affects it:

disease or condition being treated

condition of patient

age

physical and chemical stability of drug

Innovator vs generic drug - ✔✔Innovator: product developed with new

active ingredient.

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