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NUR 3050 EXAM 3 QUESTIONS WITH CORRECT ANSWERS
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NUR 3050 EXAM 3 QUESTIONS WITH CORRECT ANSWERS
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NUR 3050 EXAM 3 QUESTIONS WITHCORRECT ANSWERS
What is Lupus (SLE)? - Answer-CHRONIC, INFLAMMATORY CONNECTIVE TISSUE
D/S that affects all body systems
What is SLE characterized by? - Answer-Production of autoantibodies (antibodies that
react to the pt's own tissues which causes inflammation)
Considerations for SLE - Answer-- no cure
- periods of exacerbation and remission (which tends to improve over time)
Risk factors for SLE - Answer-- Women (usually childbearing age)
- African Americans, Hispanics, Native Americans, Asians
- Higher risk for siblings
- People with other autoimmune disease
Risk factors for Drug-induced lupus - Answer-- Sx appear 3-6 months after starting
meds
- Sx disappear when medication discont.
- Renal, CNS sx rare
- Arthritic, other systemic symptoms common
** Can be temporary
Sx can go away if med can be stopped
how do we usually dx lupus - Answer-based off collections of symptoms and complaints
(arthritis, butterfly rash)
Diagnostic testing for SLE - Answer-Anti-DNA antibody testing
Erythrocyte sedimentation rate
Serum complement levels
Complete blood count (CBC)
Pharmacologic therapy for SLE - Answer-- Immunosuppressants: Azathioprine (Imuran)
- Antineoplastic: Cyclophosphamide (Cytoxan)
- Anti-inflammatory/NSAIDS: Naproxen or Ibuprofen
- Corticosteroids: Prednisone
- Anti-malarial: Hydroxychloroquine (Plaquenil) or Chloroquine (Aralen)
common sx of SLE - Answer-- painful/achy joints (arthritis/arthralgia)
- Butterfly rash
skin manifestations of SLE - Answer-- red butterfly rash across cheeks, bridge of nose
- diffuse, maculopapular rash on skin exposed to sun
, - discoid (round, coin shaped) lesions
- erythematous fingertip lesions
- oral/nasal ulcers
- splinter hemorrhages
- alopecia
musculoskeletal manifestations - Answer-- >90% of pts have joint sx
- pain in multiple joints w/ morning stiffness
- arthritis associated with SLE rarely joint deforming
Azathioprine (Imuran) MOA + class - Answer-class:
Immunosuppressants/antimetabolite
MOA: Dampens the body's immune response - Inhibits lymphocyte replication
indication for Azathioprine (Imuran) - Answer-Used to control exacerbations; prophylaxis
Azathioprine (Imuran) SE - Answer-N/V
increase risk for infection
bone marrow suppression
malignancy (skin or hematologic)
hepatotoxicity
Nursing responsibility for Azathioprine (Imuran) - Answer-Monitor CBC + liver function,
observe for infections, administer oral prep after meals, inspect oral membranes + gum
Cyclophosphamide (Cytoxan) Class - Answer-class: Antineoplastic/Alkylating Agent
Cyclophosphamide (Cytoxan) MOA - Answer-Powerful immunosuppressant
Forms bond/linkages with DNA (process called alkylation)
Changes the shape of the DNA double helix
Prevents the nucleic acid from completing normal cell division
Used to control exacerbations; prophylaxis
Cyclophosphamide (Cytoxan) SE - Answer-Nausea, vomiting, anorexia
Alopecia
Bone marrow suppression
Steven-Johnson syndrome
Hemorrhagic cystitis
Cyclophosphamide (Cytoxan) Nursing Responsibilities - Answer-Monitor CBC and
kidney function
Observe for infections
High fluid intake during therapy
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