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BCHM 3050 Exam 3 Questions and Answers
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BCHM 3050 Exam 3 Questions and Answers
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BCHM 3050 Exam 3 Questions andAnswers
What effect does a catalyst have on the overall ΔG of a reaction? - Answer-A catalyst
has no effect on the ΔG.
Which of the following are NOT true of enzymes? - Answer-Enzymes use hydrophobic
interactions exclusively in binding substrates
if negative, The free energy change of a reaction: - Answer-enables the reaction to
occur spontaneously.
The model that best describes a conformational change in enzyme structure upon
binding substrate is referred to as: - Answer-The induced-fit model
Which of the following is the most effective way to increase the rate of a biochemical
reaction? - Answer-add a catalyst
Chymotrypsin catalyzes the hydrolysis of a peptide bond and is therefore categorized as
a _____. - Answer-Hydrolase
The highest point in a reaction coordinate diagram represents _____. - Answer-the
transition state
How does a catalyst increase the rate of a reaction? - Answer-it allows reacting
molecules to more easily form the transition state
An organic molecule that is tightly bound to an enzyme and participates in an enzyme
catalyzed reaction is specifically referred to as a _____. - Answer-prosthetic group
What three amino acids are found in the catalytic triad of chymotrypsin? - Answer-Asp,
His, Ser
In an enzyme mechanism that generates a negative charge in the transition state, which
of the following would be most effective to have in the active site of the enzyme? -
Answer-transition metal cation
The specific site on the enzyme where ______ binds and catalysis occurs is called the
______ site. - Answer-Substrate, active
How do catalysts work to accelerate a chemical reaction? - Answer-They lower the
energy of activation.;
, If the Asp in the chymotrypsin active site was mutated to another amino acid, which of
the following would be considered an invisible mutation in that it is least likely to impact
the function of the enzyme? - Answer-Asp to Glu;
How does the addition of an enzyme to a chemical reaction affect the standard free
energy of the reaction? - Answer-No effect
How does the addition of an enzyme to a chemical reaction affect the activation energy
of the reaction? - Answer-decrease
How does the addition of an enzyme to a chemical reaction affect the initial velocity of
the reaction? - Answer-Increase
Transfer of proton to aid in stabilization of intermediate - Answer-Acid Base Catalysis
Reaction coordinate has two peaks - Answer-Covalent Catalysis
Forms a transient covalent bond with the substrate - Answer-Covalent Catalysis
Often helps stabilize a negative charge in the transition state - Answer-Metal ion
catalysis
Different enzymes that catalyze the same reaction are known as _____. - Answer-
Isozymes
Hexokinase catalyzes the formation of glucose-6-phosphate through the transfer of Pi to
glucose and is therefore categorized as a _____. - Answer-Transferase
Match the reactions below with the correct class of enzyme. - Answer-Transferase
isomerase ligase Oxidoreductase lyase hydrolase
In the simple enzyme-catalyzed reaction below, which of the rate constants would be
second-order? - Answer-K1
A graph of reaction velocity as a function of substrate concentration would yield a
______ curve for a Michaelis-Menten enzyme. - Answer-Hyperbolic
Which of the following would be a proper representation of enzyme velocity? - Answer-E
A new drug has been discovered which inhibits the reaction catalyzed by enzyme A.
Based on the information shown below, what is this drug? - Answer-competitive inhibitor
______ enzyme inhibitors irreversibly bind the enzyme, inactivating it. - Answer-Suicide
When [S] = KM, V0 = (_____) × (Vmax). - Answer-.5
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