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PHM 350 EXAM 1 EXAM QUESTIONS AND VERIFIED ANSWERS (LATEST UPDATE )
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QUESTIONS AND ANSWERS
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PHM 350 EXAM 1 EXAMQUESTIONS AND VERIFIED
ANSWERS (LATEST UPDATE
2024-2025)
If the volume of distribu1on of a drug is calculated to be the same as plasma
volume, then one should conclude that:
A. The drug has been eliminated before plasma drug concentra1on was
measured.
ÖÖ B. The drug did not leave the systemic circula1on.
C. The drug is present in the blood and the extracellular extravascular space
but is absent from the intracellular space.
D. The drug is sequestered to cells of a single organ or to a specific organelle
within cells.
E. None of the above
B
The Therapeu1c Range of a drug:
ÖÖ A. Is the range of plasma concentra1on of the drug in which the drug
produces the desired therapeu1c without producing any toxic effects or
adverse side effects also produced.
B. Can only be determined for antagonist drugs.
C. Can only be determined for agonist drugs.
D. Is the range of plasma concentra1on of the drug in which the drug produces
the desired therapeu1c effect regardless of any toxic effects or adverse side
effects also produced
,A
The bioavailability of a drug administered orally (and swallowed!!!) Is 0.9.
Given this informa1on, you conclude that for an orally administered dose of
this drug:
A. This drug is rapidly eliminated.
B. This drug is slowly eliminated.
ÖÖ C. Most of an orally administered dose of this drug is absorbed into the
blood.
D. This drug will likely have insignificant therapeu1c benefits if those benefits
require the drug to enter the systemic
C
The Kd for a drug is:
A. Defined as the concentra1on of drug necessary to product 50% of the
maximum response when receptors are ac1vated
ÖÖ B. Defined as the concentra1on of drug at which 50% of the receptors in a
given popula1on will each be bound by a molecule of the drug (with the
remaining receptors being unoccupied by drug)
C. Defined as the concentra1on of drug required to inhibit an agonist response
by 50% assuming sufficient agonist s present to produce a response that is
100% of the maximum response
D. Defined as the concentra1on of drug necessary to inhibit agonist binding by
50% assuming sufficient agonist is present to bind to 100% of the receptors
B
You are given the same oral dose of a drug every 24 hours. By the sixth day, the
drug seems to have a reduced effec1veness (compared to its effect on the first
couple of days). This reduced effec1veness could be the result of:
A. Increased rate of delivery of the drug from the plasma to its sites of ac1on
,and increased affinity of the drug for the receptors through which the response
is induced.
B. Increased affinity of the drug for the receptors through which the response
is induced.
C. Increased rate of delivery of the drug from the plasma to its sites of ac1on.
ÖÖ D. Decreased absorp1on of drug from the gastrointes1nal tract.
E. Decreased rate of elimina1on
D
The liver enzyme Enzyme Z metabolizes Drug A. If Drug A is administered
repeatedly, then the amount of Enzyme Z in the liver is increased.
Consequently....
A. The rate of metabolism of Drug A will not change.
B. The rate of metabolism of any drug metabolized by Enzyme Z is decreased.
ÖÖ C. The half-life of all drugs metabolized by Enzyme Z will be decreased
D. The half-life of Drug A will be increased.
E. The half-life of Drug B, also metabolized by Enzyme Z, will not be affected
C
When a drug is dissolved in an aqueous (water-based) solu1on, the
concentra1on of ionized form of the drug is dependent on:
A. The acidity (ph) of the aqueous solu1on.
B. The lipid solubility of the drug.
C. The pka of the drug.
D. The amount of drug dissolved in the solu1on.
ÖÖ E. The acidity (ph) of the aqueous solu1on, and the pka of the drug, and the
amount of the drug dissolved in the solu1on
E
, Drug A is administered repeatedly with a constant interval between
consecu1ve doses and with a constant dose. The mean plasma concentra1on
of Drug A is measured. The concentra1on:
A. Is independent on the route of administra1on but is dependent on the dose
and the interval between consecu1ve doses.
B. Is independent of the clearance volume for the drug.
C. Is independent of the route of administra1on
D. Is independent of the dose of drug administered but not of the interval
between consecu1ve doses
ÖÖ E. Is dependent on the dose and the interval between consecu1ve doses
E
The therapeu1c threshold concentra1on (aka minimal effec1ve concentra1on)
of a drug:
A. Determines the pharmacological and clinical (or physiological) efficacies of
the drug.
B. Is affected by the ability of the body to eliminate (metabolize and/or excrete)
the drug and depends on the rate of absorp1on of the drug.
C. Depends on the rate of absorp1on of the drug.
D. Is affected by the ability of the body to eliminate (metabolize and/or excrete)
the drug.
ÖÖ E. Is the minimum plasma concentra1on of the drug which is required to
induce the desired therapeu1c response
E
Clearance Volume of a drug:
A. Indicated whether the drug is preferen1ally distributed to the brain and
spinal cord
B. Is a measured quan1ty
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