Exam (elaborations)
PHM 350 EXAM 1 QUESTIONS & ANSWERS SOVED 100% CORRECT!!
- Course
- Institution
PHM 350 EXAM 1 QUESTIONS & ANSWERS SOVED 100% CORRECT!!
[Show more]
Content preview
PHM 350 EXAM 1 QUESTIONS & ANSWERSSOVED 100% CORRECT!!
in the figure (#1) you can see how the concentration of four different drugs - A,
B, C,& D - in the plasma changes with time. Each drug was administered only
after complete elimination of the previously administered drug and the same
dose of each drug was administered.
Drugs were administered orally, at the time point shown by the arrow.
"ThTC" is the Therapeutic Threshold Concentration and
"ToTC" is the Toxic Threshold Concentration of the drug. Select the drug which
best matches this statement:
At the dose administered, this drug will not have any effect Answer - Drug B
in the figures below (#2), you can see how the concentration of four different
drugs - A, B, C,& D - in the plasma changes with time.
The rates of absorption and elimination of the four drugs are the same and the
same dose of each drug was administered. Drugs were administered orally, at
the time point shown by the arrow.
"ThTC" is theTherapeutic Threshold Concentration and
"ToTC" is the Toxic Threshold Concentration of the drug.
Select the drug which best matches this statement:
this drug has the largest therapeutic range: Answer - Drug D
,A drug is totally eliminated by excretion in the urine. Which of the following
will produce an increase of concentration of free drug in the plasma?
A. Reabsorption of drug from the renal tubule
B. Displacement of drug from plasma protein (albumin) binding sites
C. Reduction in activity of drug metabolizing enzymes in the liver
D. A and B, above
E. B and C, above Answer - D. A and B,
For a drug which is eliminated following zero order kinetics:
A. The rate of elimination (as g/min or some similar units) is greater when the
plasma concentration of the drug is low compared to when the plasma
concentration of the drug is high
B. The rate of elimination is independent of the plasma concentration of the
drug
C. The rate of elimination (as g/min or some similar units) is greater when the
plasma concentration of the drug is high compared to when the plasma
concentration of the drug is low
D. The rate of elimination can not be determined
E. Elimination is by metabolism of the drug not by excretion Answer - B. The
rate of elimination is independent of the plasma concentration of the drug
When two drugs, Drug A and Drug B, which are both substrates for the same
drug metabolizing enzyme, are present:
A. The change of rate of metabolism of Drug A (compared to the rate of
metabolism when only Drug A is present) depends on the affinity of Drug B and
of Drug A for the enzyme
B. There is no effect on the rate of metabolism of these drugs
C. The rate of metabolism of both drugs is increased (compared to the rate of
metabolism when only one drug is present)
,D. The rate of metabolism of the drugs will only change if their metabolism
follows zero order kinetics
E. A and C, above. Answer - A. The change of rate of metabolism of Drug A
(compared to the rate of metabolism when only Drug A is present) depends on
the affinity of Drug B and of Drug A for the enzyme
The liver enzyme Enzyme Z metabolizes Drug A. If Drug A is administered
repeatedly, then the amount of Enzyme Z in the liver is increased.
Consequently....
A. The half-life of Drug A will be increased
B. The half life of Drug B, also metabolized by Enzyme Z, will not be affected
C. The half-life of all drugs metabolized by Enzyme Z will be decreased
D. The rate of metabolism of Drug A will not change
E. A and C, above. Answer - C. The half-life of all drugs metabolized by Enzyme
Z will be decreased
The bioavailability of a drug administered orally (and swallowed!!) is 0.9. Given
this information, you conclude that for an orally administered dose of this drug:
A. This drug is rapidly eliminated
B. Most of an orally administered dose of this drug is absorbed into the blood
C. This drug will likely have insignificant therapeutic benefits if those benefits
require the drug to enter the systemic circulation
D. This drug is very slowly eliminated
E. A and C, above. Answer - B. Most of an orally administered dose of this drug
is absorbed into the blood
The half-life of drug X, eliminated according to first order kinetics, is 75minutes.
Drug X is administered by intravenous injection. After injection, at a time
designated 0minute, the concentration of drug X was 500mg/ml. After 2hours
30minutes, the concentration of drug X will be:
, A. 500mg/ml
B. 250mg/ml
C. 125mg/ml
D. 62.5mg/ml
E. 31.25mg/ml. Answer - C. 125mg/ml
The therapeutic threshold concentration (aka minimal effective concentration)
of a drug:
A. Is affected by the ability of the body to eliminate (metabolize and/or excrete)
the drug
B. Is the minimum plasma concentration of the drug which is required to
induce the desired therapeutic response
C. Depends on the rate of absorption of the drug
D. Determines the pharmacological and clinical (or
physiological) efficacies of the drug
E. A and C, above. Answer - B. Is the minimum plasma concentration of the
drug which is required to induce the desired therapeutic response
The duration of action of a drug given in a single dose (assuming the drug must
enter the blood to have action):
A. Is independent of the latency to action for the drug
B. Is longer if the drug is excreted without metabolism than if it is eliminated
only by metabolism
C. Is generally longer if the drug is injected intravenously than if the drug is
taken orally
D. Depends on the latency to action for the drug
E. A and C, above. Answer - A. Is independent of the latency to action for the
drug
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller EvaTee. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $27.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
81298 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now